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dc.contributor.authorWebb, TR
dc.contributor.authorErdmann, J
dc.contributor.authorStirrups, KE
dc.contributor.authorStitziel, NO
dc.contributor.authorMasca, NGD
dc.contributor.authorJansen, H
dc.contributor.authorKanoni, S
dc.contributor.authorNelson, CP
dc.contributor.authorFerrario, PG
dc.contributor.authorKönig, IR
dc.contributor.authorEicher, JD
dc.contributor.authorJohnson, AD
dc.contributor.authorHamby, SE
dc.contributor.authorBetsholtz, C
dc.contributor.authorRuusalepp, A
dc.contributor.authorFranzén, O
dc.contributor.authorSchadt, EE
dc.contributor.authorBjörkegren, JLM
dc.contributor.authorWeeke, PE
dc.contributor.authorAuer, PL
dc.contributor.authorSchick, UM
dc.contributor.authorLu, Y
dc.contributor.authorZhang, H
dc.contributor.authorDube, M-P
dc.contributor.authorGoel, A
dc.contributor.authorFarrall, M
dc.contributor.authorPeloso, GM
dc.contributor.authorWon, H-H
dc.contributor.authorDo, R
dc.contributor.authorvan Iperen, E
dc.contributor.authorKruppa, J
dc.contributor.authorMahajan, A
dc.contributor.authorScott, RA
dc.contributor.authorWillenborg, C
dc.contributor.authorBraund, PS
dc.contributor.authorvan Capelleveen, JC
dc.contributor.authorDoney, ASF
dc.contributor.authorDonnelly, LA
dc.contributor.authorAsselta, R
dc.contributor.authorMerlini, PA
dc.contributor.authorDuga, S
dc.contributor.authorMarziliano, N
dc.contributor.authorDenny, JC
dc.contributor.authorShaffer, C
dc.contributor.authorEl-Mokhtari, NE
dc.contributor.authorFranke, A
dc.contributor.authorHeilmann, S
dc.contributor.authorHengstenberg, C
dc.contributor.authorHoffmann, P
dc.contributor.authorHolmen, OL
dc.contributor.authorHveem, K
dc.contributor.authorJansson, J-H
dc.contributor.authorJöckel, K-H
dc.contributor.authorKessler, T
dc.contributor.authorKriebel, J
dc.contributor.authorLaugwitz, KL
dc.contributor.authorMarouli, E
dc.contributor.authorMartinelli, N
dc.contributor.authorMcCarthy, MI
dc.contributor.authorVan Zuydam, NR
dc.contributor.authorMeisinger, C
dc.contributor.authorEsko, T
dc.contributor.authorMihailov, E
dc.contributor.authorEscher, SA
dc.contributor.authorAlver, M
dc.contributor.authorMoebus, S
dc.contributor.authorMorris, AD
dc.contributor.authorVirtamo, J
dc.contributor.authorNikpay, M
dc.contributor.authorOlivieri, O
dc.contributor.authorProvost, S
dc.contributor.authorAlQarawi, A
dc.contributor.authorRobertson, NR
dc.contributor.authorAkinsansya, KO
dc.contributor.authorReilly, DF
dc.contributor.authorVogt, TF
dc.contributor.authorYin, W
dc.contributor.authorAsselbergs, FW
dc.contributor.authorKooperberg, C
dc.contributor.authorJackson, RD
dc.contributor.authorStahl, E
dc.contributor.authorMüller-Nurasyid, M
dc.contributor.authorStrauch, K
dc.contributor.authorVarga, TV
dc.contributor.authorWaldenberger, M
dc.contributor.authorWellcome Trust Case Control Consortium
dc.contributor.authorZeng, L
dc.contributor.authorChowdhury, R
dc.contributor.authorSalomaa, V
dc.contributor.authorFord, I
dc.contributor.authorJukema, JW
dc.contributor.authorAmouyel, P
dc.contributor.authorKontto, J
dc.contributor.authorMORGAM Investigators
dc.contributor.authorNordestgaard, BG
dc.contributor.authorFerrières, J
dc.contributor.authorSaleheen, D
dc.contributor.authorSattar, N
dc.contributor.authorSurendran, P
dc.contributor.authorWagner, A
dc.contributor.authorYoung, R
dc.contributor.authorHowson, JMM
dc.contributor.authorButterworth, AS
dc.contributor.authorDanesh, J
dc.contributor.authorArdissino, D
dc.contributor.authorBottinger, EP
dc.contributor.authorErbel, R
dc.contributor.authorFranks, PW
dc.contributor.authorGirelli, D
dc.contributor.authorHall, AS
dc.contributor.authorHovingh, GK
dc.contributor.authorKastrati, A
dc.contributor.authorLieb, W
dc.contributor.authorMeitinger, T
dc.contributor.authorKraus, WE
dc.contributor.authorShah, SH
dc.contributor.authorMcPherson, R
dc.contributor.authorOrho-Melander, M
dc.contributor.authorMelander, O
dc.contributor.authorMetspalu, A
dc.contributor.authorPalmer, CNA
dc.contributor.authorPeters, A
dc.contributor.authorRader, DJ
dc.contributor.authorReilly, MP
dc.contributor.authorLoos, RJF
dc.contributor.authorReiner, AP
dc.contributor.authorRoden, DM
dc.contributor.authorTardif, J-C
dc.contributor.authorThompson, JR
dc.contributor.authorWareham, NJ
dc.contributor.authorWatkins, H
dc.contributor.authorWiller, CJ
dc.contributor.authorSamani, NJ
dc.contributor.authorSchunkert, H
dc.contributor.authorDeloukas, P
dc.contributor.authorKathiresan, S
dc.contributor.authorMyocardial Infarction Genetics and CARDIoGRAM Exome Consortia Investigators
dc.date.accessioned2017-03-03T11:14:48Z
dc.date.available2017-03-03T11:14:48Z
dc.date.issued2017-02-21
dc.date.submitted2017-02-26T08:43:48.851Z
dc.identifier.issn0735-1097
dc.identifier.urihttp://qmro.qmul.ac.uk/xmlui/handle/123456789/19641
dc.description.abstractBACKGROUND: Genome-wide association studies have so far identified 56 loci associated with risk of coronary artery disease (CAD). Many CAD loci show pleiotropy; that is, they are also associated with other diseases or traits. OBJECTIVES: This study sought to systematically test if genetic variants identified for non-CAD diseases/traits also associate with CAD and to undertake a comprehensive analysis of the extent of pleiotropy of all CAD loci. METHODS: In discovery analyses involving 42,335 CAD cases and 78,240 control subjects we tested the association of 29,383 common (minor allele frequency >5%) single nucleotide polymorphisms available on the exome array, which included a substantial proportion of known or suspected single nucleotide polymorphisms associated with common diseases or traits as of 2011. Suggestive association signals were replicated in an additional 30,533 cases and 42,530 control subjects. To evaluate pleiotropy, we tested CAD loci for association with cardiovascular risk factors (lipid traits, blood pressure phenotypes, body mass index, diabetes, and smoking behavior), as well as with other diseases/traits through interrogation of currently available genome-wide association study catalogs. RESULTS: We identified 6 new loci associated with CAD at genome-wide significance: on 2q37 (KCNJ13-GIGYF2), 6p21 (C2), 11p15 (MRVI1-CTR9), 12q13 (LRP1), 12q24 (SCARB1), and 16q13 (CETP). Risk allele frequencies ranged from 0.15 to 0.86, and odds ratio per copy of the risk allele ranged from 1.04 to 1.09. Of 62 new and known CAD loci, 24 (38.7%) showed statistical association with a traditional cardiovascular risk factor, with some showing multiple associations, and 29 (47%) showed associations at p < 1 × 10(-4) with a range of other diseases/traits. CONCLUSIONS: We identified 6 loci associated with CAD at genome-wide significance. Several CAD loci show substantial pleiotropy, which may help us understand the mechanisms by which these loci affect CAD risk.en_US
dc.description.sponsorshipBritish Heart Foundationen_US
dc.format.extent823 - 836
dc.languageeng
dc.language.isoenen_US
dc.publisherElsevier on behalf of the American College of Cardiology Foundationen_US
dc.relation.ispartofJ Am Coll Cardiol
dc.rightsTHIS IS AN OPEN ACCESS ARTICLE UNDER THE CC BY LICENSE ( http://creativecommons.org/licenses/by/4.0/ )
dc.subjectcholesteryl ester transfer proteinen_US
dc.subjectexpression quantitative trait locien_US
dc.subjectgeneticsen_US
dc.subjectgenome-wide associationen_US
dc.subjectsingle nucleotide polymorphismen_US
dc.titleSystematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease.en_US
dc.typeArticleen_US
dc.rights.holder(c) 2017 the Authors.
dc.identifier.doi10.1016/j.jacc.2016.11.056
pubs.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/28209224
pubs.issue7
pubs.organisational-group/Queen Mary University of London
pubs.organisational-group/Queen Mary University of London/Faculty of Medicine & Dentistry
pubs.organisational-group/Queen Mary University of London/Faculty of Medicine & Dentistry/William Harvey Research Institute
pubs.organisational-group/Queen Mary University of London/Faculty of Medicine & Dentistry/William Harvey Research Institute/Clinical Pharmacology
pubs.publication-statusPublished
pubs.volume69


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