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    Albumin Extravasation During Surgery 
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    Albumin Extravasation During Surgery

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    Grogono_A_PhD_Final_1975 (11.46Mb)
    Grogono_A_PhD_Final_1975_corrected version (9.117Mb)
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    Abstract
    This thesis is concerned with the measurement of changes in the circulation during the period of surgery. A loss of albumin from the circulation is to be expected from observations and experiments made in the postoperative period. In this thesis a sensitive measurement technique is described which allows extravasation of albumin to be studied in patients undergoing elective surgery. Radio-isotope labelled albumin and radio-isotope labelled red cells are injected; the ratio between the two is not affected by blood loss or infusion and the ratio is therefore used as a measure of albumin extravasation. To measure the relative loss of albumin from the circulation the isotopes were administered some days prior to surgery to allow distribution and equilibration of the albumin. To measure the rate of loss of albumin (capillary permeability) the isotopes were administered at the time of surgery. The results indicate that major surgery under general anaesthesia is accompanied by a loss of albumin from the circulation, an increased capillary permeability to albumin and a fall in plasma volume that is greater than can be explained on the basis of blood loss and greater than would be expected on the basis of the reduction in red cell volume. The results suggest that patients who receive only glucose and salt solutions intravenously during major surgery will usually suffer a contraction in their blood volumes unless unacceptably large volumes of fluid are infused.
    Authors
    Grogono, A
    URI
    http://qmro.qmul.ac.uk/xmlui/handle/123456789/18972
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    • Theses [3822]
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    This thesis is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
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