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dc.contributor.authorDe Bari, Cen_US
dc.contributor.authorDell'Accio, Fen_US
dc.contributor.authorVandenabeele, Fen_US
dc.contributor.authorVermeesch, JRen_US
dc.contributor.authorRaymackers, J-Men_US
dc.contributor.authorLuyten, FPen_US
dc.date.accessioned2017-01-06T15:07:14Z
dc.date.issued2003-03-17en_US
dc.date.submitted2016-12-26T20:59:06.535Z
dc.identifier.issn0021-9525en_US
dc.identifier.urihttp://qmro.qmul.ac.uk/xmlui/handle/123456789/18432
dc.description.abstractWe have demonstrated previously that adult human synovial membrane-derived mesenchymal stem cells (hSM-MSCs) have myogenic potential in vitro (De Bari, C., F. Dell'Accio, P. Tylzanowski, and F.P. Luyten. 2001. Arthritis Rheum. 44:1928-1942). In the present study, we have characterized their myogenic differentiation in a nude mouse model of skeletal muscle regeneration and provide proof of principle of their potential use for muscle repair in the mdx mouse model of Duchenne muscular dystrophy. When implanted into regenerating nude mouse muscle, hSM-MSCs contributed to myofibers and to long term persisting functional satellite cells. No nuclear fusion hybrids were observed between donor human cells and host mouse muscle cells. Myogenic differentiation proceeded through a molecular cascade resembling embryonic muscle development. Differentiation was sensitive to environmental cues, since hSM-MSCs injected into the bloodstream engrafted in several tissues, but acquired the muscle phenotype only within skeletal muscle. When administered into dystrophic muscles of immunosuppressed mdx mice, hSM-MSCs restored sarcolemmal expression of dystrophin, reduced central nucleation, and rescued the expression of mouse mechano growth factor.en_US
dc.format.extent909 - 918en_US
dc.languageengen_US
dc.language.isoenen_US
dc.relation.ispartofJ Cell Biolen_US
dc.rightsCC-BY--NC-SA
dc.subjectAdolescenten_US
dc.subjectAdulten_US
dc.subjectAgeden_US
dc.subjectAged, 80 and overen_US
dc.subjectAnimalsen_US
dc.subjectCell Differentiationen_US
dc.subjectCell Lineageen_US
dc.subjectCells, Cultureden_US
dc.subjectDisease Models, Animalen_US
dc.subjectFemaleen_US
dc.subjectHumansen_US
dc.subjectMesodermen_US
dc.subjectMiceen_US
dc.subjectMice, Inbred mdxen_US
dc.subjectMice, Knockouten_US
dc.subjectMice, Nudeen_US
dc.subjectMiddle Ageden_US
dc.subjectMuscle Fibers, Skeletalen_US
dc.subjectMuscle, Skeletalen_US
dc.subjectMuscular Dystrophy, Animalen_US
dc.subjectSatellite Cells, Skeletal Muscleen_US
dc.subjectStem Cell Transplantationen_US
dc.subjectStem Cellsen_US
dc.subjectSynovial Membraneen_US
dc.titleSkeletal muscle repair by adult human mesenchymal stem cells from synovial membrane.en_US
dc.typeArticle
dc.rights.holder© 2003 Rockefeller University Press
dc.identifier.doi10.1083/jcb.200212064en_US
pubs.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/12629053en_US
pubs.issue6en_US
pubs.notesNot knownen_US
pubs.publication-statusPublisheden_US
pubs.volume160en_US


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