Show simple item record

dc.contributor.authorJolliffe, DAen_US
dc.contributor.authorKilpin, Ken_US
dc.contributor.authorMacLaughlin, BDen_US
dc.contributor.authorGreiller, CLen_US
dc.contributor.authorHooper, RLen_US
dc.contributor.authorBarnes, NCen_US
dc.contributor.authorTimms, PMen_US
dc.contributor.authorRajakulasingam, RKen_US
dc.contributor.authorBhowmik, Aen_US
dc.contributor.authorChoudhury, ABen_US
dc.contributor.authorSimcock, DEen_US
dc.contributor.authorHyppönen, Een_US
dc.contributor.authorCorrigan, CJen_US
dc.contributor.authorWalton, RTen_US
dc.contributor.authorGriffiths, CJen_US
dc.contributor.authorMartineau, ARen_US
dc.date.accessioned2016-12-12T15:04:43Z
dc.date.available2016-11-03en_US
dc.date.issued2018-01en_US
dc.date.submitted2016-11-12T07:10:49.405Z
dc.identifier.urihttp://qmro.qmul.ac.uk/xmlui/handle/123456789/18199
dc.description.abstractVitamin D deficiency is common in children with asthma, and it associates with poor asthma control, reduced forced expiratory volume in one second (FEV1) and increased requirement for inhaled corticosteroids (ICS). Cross-sectional studies investigating the prevalence, determinants and clinical correlates of vitamin D deficiency in adults with asthma are lacking. We conducted a multi-centre cross-sectional study in 297 adults with a medical record diagnosis of ICS-treated asthma living in London, UK. Details of potential environmental determinants of vitamin D status, asthma control and medication use were collected by questionnaire; blood samples were taken for analysis of serum 25(OH)D concentration and DNA extraction, and participants underwent measurement of weight, height and fractional exhaled nitric oxide concentration (FeNO), spirometry and sputum induction for determination of lower airway eosinophil counts (n=35 sub-group). Thirty-five single nucleotide polymorphisms (SNP) in 11 vitamin D pathway genes (DBP, DHCR7, RXRA, CYP2R1, CYP27B1, CYP24A1, CYP3A4 CYP27A1, LRP2, CUBN, VDR) were typed using Taqman allelic discrimination assays. Linear regression was used to identify environmental and genetic factors independently associated with serum 25(OH)D concentration, and to determine whether vitamin D status was independently associated with Asthma Control Test (ACT) score, ICS dose, FeNO, forced vital capacity (FVC), FEV1 or lower airway eosinophilia. Mean serum 25(OH)D concentration was 50.6nmol/L (SD 24.9); 162/297 (54.5%) participants were vitamin D deficient (serum 25(OH)D concentration <50nmol/L). Lower vitamin D status was associated with higher body mass index (P=0.014), non-White ethnicity (P=0.036), unemployment (P for trend=0.012), lack of vitamin D supplement use (P<0.001), sampling in Winter or Spring (P for trend <0.001) and lack of a recent sunny holiday abroad (P=0.030), but not with potential genetic determinants. Vitamin D status was not found to associate with any marker of asthma control investigated. Vitamin D deficiency is common among UK adults with ICS-treated asthma, and classical environmental determinants of serum 25(OH)D operate in this population. However, in contrast to studies conducted in children, we found no association between vitamin D status and markers of asthma severity or control.en_US
dc.description.sponsorshipThis is a summary of independent research funded by the National Institute for Health Research (NIHR) under its Programme Grants for Applied Research Programme (Reference Number RP-PG-0407-10398).en_US
dc.format.extent88 - 96en_US
dc.languageengen_US
dc.relation.ispartofJ Steroid Biochem Mol Biolen_US
dc.rights© 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectAsthmaen_US
dc.subjectCross-sectionalen_US
dc.subjectEnvironmentalen_US
dc.subjectGeneticsen_US
dc.subjectPhenotypeen_US
dc.subjectVitamin Den_US
dc.subjectAdministration, Inhalationen_US
dc.subjectAdolescenten_US
dc.subjectAdrenal Cortex Hormonesen_US
dc.subjectAdulten_US
dc.subjectAgeden_US
dc.subjectAnti-Asthmatic Agentsen_US
dc.subjectAsthmaen_US
dc.subjectBody Mass Indexen_US
dc.subjectContinental Population Groupsen_US
dc.subjectCross-Sectional Studiesen_US
dc.subjectCytochrome P-450 Enzyme Systemen_US
dc.subjectDNA-Binding Proteinsen_US
dc.subjectEosinophilsen_US
dc.subjectFemaleen_US
dc.subjectGene Expression Regulationen_US
dc.subjectHumansen_US
dc.subjectLondonen_US
dc.subjectLow Density Lipoprotein Receptor-Related Protein-2en_US
dc.subjectMaleen_US
dc.subjectMiddle Ageden_US
dc.subjectOxidoreductases Acting on CH-CH Group Donorsen_US
dc.subjectReceptors, Calcitriolen_US
dc.subjectReceptors, Cell Surfaceen_US
dc.subjectRespiratory Function Testsen_US
dc.subjectSeverity of Illness Indexen_US
dc.subjectTranscription Factorsen_US
dc.subjectVitamin Den_US
dc.subjectVitamin D Deficiencyen_US
dc.titlePrevalence, determinants and clinical correlates of vitamin D deficiency in adults with inhaled corticosteroid-treated asthma in London, UK.en_US
dc.typeArticle
dc.rights.holderCrown Copyright © 2016 Published by Elsevier Ltd. All rights reserved.
dc.identifier.doi10.1016/j.jsbmb.2016.11.004en_US
pubs.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/27825992en_US
pubs.notesNot knownen_US
pubs.publication-statusPublisheden_US
pubs.volume175en_US
dcterms.dateAccepted2016-11-03en_US


Files in this item

Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record