Miner, Wesley: transcript of an audio interview (15-Jul-2016)

Abstract

Interview with Mr Wesley Miner, conducted by Professor Tilli Tansey, for the History of Modern Biomedicine Research Group, 15 July 2016, in the School of History, Queen Mary University of London. Transcribed by Mrs Debra Gee, and edited by Professor Tilli Tansey and Mr Adam Wilkinson. The technical support was provided by Mr Alan Yabsley. Mr Wesley Miner BSc (b. 1948) is a graduate in physiology from the University of Edinburgh. From 1982 to 1986 he worked at Beecham Pharmaceuticals (GlaxoSmithKline since 2000) with Gareth Sanger. During this time, Miner and Sanger discovered, and were the first to publish that serotonin receptor type 3 (5-HT3) antagonists were extremely efficacious pharmacological agents for preventing and treating anti-cancer therapy (chemo and radiation) induced nausea and vomiting (Miner and Sanger, 1986). This seminal experimental work translated very well to the clinic when granisetron (Kytril) was shown to be highly efficacious in patients. Importantly, this discovery became one of a very select few where research into 5-HT mechanisms actually culminated in a marketable drug that markedly improved the quality of life for patients. Following this ground-breaking research at Beecham, he relocated to another major international pharmaceutical company and became a key member of the biology team that discovered darifenacin (M3 selective antimuscarinic), which is now indicated and marketed for over active bladder and urinary incontinence.