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dc.contributor.authorGenina, EA
dc.contributor.authorSvenskaya, YI
dc.contributor.authorYanina, IY
dc.contributor.authorDolotov, LE
dc.contributor.authorNavolokin, NA
dc.contributor.authorBashkatov, AN
dc.contributor.authorTerentyuk, GS
dc.contributor.authorBucharskaya, AB
dc.contributor.authorMaslyakova, GN
dc.contributor.authorGorin, DA
dc.contributor.authorTuchin, VV
dc.contributor.authorSukhorukov, GB
dc.description.abstractWe have developed a method for delivery of biocompatible CaCO3 microcontainers (4.0 ± 0.8 µm) containing Fe3O4 nanoparticles (14 ± 5 nm) into skin in vivo using fractional laser microablation (FLMA) provided by a pulsed Er:YAG laser system. Six laboratory rats have been used for the microcontainer delivery and weekly monitoring implemented using an optical coherence tomography and a standard histological analysis. The use of FLMA allowed for delivery of the microcontainers to the depth about 300 μm and creation of a depot in dermis. On the seventh day we have observed the dissolving of the microcontainers and the release of nanoparticles into dermis.
dc.description.sponsorshipThe research was supported by the Government of the RF (grant 14.Z50.31.0004 to support scientific research projects implemented under the supervision of leading scientists).en_US
dc.format.extent2082 - 2087
dc.subject(110.4500) Optical coherence tomography
dc.subject(170.0170) Medical optics and biotechnology
dc.subject(170.0180) Microscopy
dc.subject(170.1020) Ablation of tissue
dc.subject(350.4990) Particles
dc.titleIn vivo optical monitoring of transcutaneous delivery of calcium carbonate microcontainers.
dc.typeJournal Article
dc.rights.holder2016 OSA
dc.relation.isPartOfBiomedical Optics Express
dc.relation.isPartOfBiomed Opt Express
dc.relation.isPartOfBiomed Opt Express
pubs.organisational-group/Queen Mary University of London
pubs.organisational-group/Queen Mary University of London/Faculty of Science & Engineering
pubs.organisational-group/Queen Mary University of London/Faculty of Science & Engineering/Engineering and Materials Science - Staff
pubs.publication-statusPublished online

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