In vivo optical monitoring of transcutaneous delivery of calcium carbonate microcontainers.
2082 - 2087
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We have developed a method for delivery of biocompatible CaCO3 microcontainers (4.0 ± 0.8 µm) containing Fe3O4 nanoparticles (14 ± 5 nm) into skin in vivo using fractional laser microablation (FLMA) provided by a pulsed Er:YAG laser system. Six laboratory rats have been used for the microcontainer delivery and weekly monitoring implemented using an optical coherence tomography and a standard histological analysis. The use of FLMA allowed for delivery of the microcontainers to the depth about 300 μm and creation of a depot in dermis. On the seventh day we have observed the dissolving of the microcontainers and the release of nanoparticles into dermis.
AuthorsGenina, EA; Svenskaya, YI; Yanina, IY; Dolotov, LE; Navolokin, NA; Bashkatov, AN; Terentyuk, GS; Bucharskaya, AB; Maslyakova, GN; Gorin, DA; Tuchin, VV; Sukhorukov, GB
- College Publications