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dc.contributor.authorGroppi, Jessica
dc.date.accessioned2016-06-13T11:18:16Z
dc.date.available2016-06-13T11:18:16Z
dc.date.issued2016-02-15
dc.date.submitted2016-06-13T12:01:13.429Z
dc.identifier.citationGroppi, J, Toward the Control of Partial Covalent Modification of Glassy Carbon Surfaces, Queen Mary University of London.en_US
dc.identifier.urihttp://qmro.qmul.ac.uk/xmlui/handle/123456789/12822
dc.descriptionPhDen_US
dc.description.abstractThe patterning of surfaces with control over the relative ratios of different components represents one of the goals in the creation of devices for biosensing and energy storage, since it could improve the stability and sensitivity of the response. Considering this, a general methodology for the creation of controlled mixed monolayers on glassy carbon (GC) surfaces was developed, using osmium bipyridyl complexes and anthraquinone as model redox probes, but potentially applicable to more complex systems. The work consisted in the electrochemical grafting on GC of a mixture of diamine linkers in different ratios and characterised by protecting groups which allowed orthogonal deprotection. After optimisation of the deprotection conditions, it was possible to selectively remove one of the protecting groups, couple a suitable osmium complex and cap the residual free amines. The removal of the second protecting group allowed the coupling of anthraquinone. The characterisation of the surfaces by cyclic voltammetry showed the variation of the surface coverage of the two redox centres in relation to the initial ratio of the linking amine in solution. It was then possible to build patterned surfaces where the osmium complex acted as mediator for Glucose dehydrogenase (GDH), covalently bonded to GC through an exposed cysteine residue to a maleimide moiety.en_US
dc.language.isoenen_US
dc.publisherQueen Mary University of Londonen_US
dc.subjectBiological and Chemical Sciencesen_US
dc.titleToward the Control of Partial Covalent Modification of Glassy Carbon Surfacesen_US
dc.typeThesisen_US
dc.rights.holderThe copyright of this thesis rests with the author and no quotation from it or information derived from it may be published without the prior written consent of the author


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    Theses Awarded by Queen Mary University of London

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