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    Molecular evolutionary characterization of a V1R subfamily unique to strepsirrhine primates. 
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    Molecular evolutionary characterization of a V1R subfamily unique to strepsirrhine primates.

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    Yoder Molecular evolutionary characterization of a V1R subfamily unique to strepsirrhine primates 2014 Published.pdf (1.395Mb)
    Volume
    6
    Pagination
    213 - 227
    DOI
    10.1093/gbe/evu006
    Journal
    Genome Biol Evol
    Issue
    1
    Metadata
    Show full item record
    Abstract
    Vomeronasal receptor genes have frequently been invoked as integral to the establishment and maintenance of species boundaries among mammals due to the elaborate one-to-one correspondence between semiochemical signals and neuronal sensory inputs. Here, we report the most extensive sample of vomeronasal receptor class 1 (V1R) sequences ever generated for a diverse yet phylogenetically coherent group of mammals, the tooth-combed primates (suborder Strepsirrhini). Phylogenetic analysis confirms our intensive sampling from a single V1R subfamily, apparently unique to the strepsirrhine primates. We designate this subfamily as V1Rstrep. The subfamily retains extensive repertoires of gene copies that descend from an ancestral gene duplication that appears to have occurred prior to the diversification of all lemuriform primates excluding the basal genus Daubentonia (the aye-aye). We refer to the descendent clades as V1Rstrep-α and V1Rstrep-β. Comparison of the two clades reveals different amino acid compositions corresponding to the predicted ligand-binding site and thus potentially to altered functional profiles between the two. In agreement with previous studies of the mouse lemur (genus, Microcebus), the majority of V1Rstrep gene copies appear to be intact and under strong positive selection, particularly within transmembrane regions. Finally, despite the surprisingly high number of gene copies identified in this study, it is nonetheless probable that V1R diversity remains underestimated in these nonmodel primates and that complete characterization will be limited until high-coverage assembled genomes are available.
    Authors
    Yoder, AD; Chan, LM; dos Reis, M; Larsen, PA; Campbell, CR; Rasoloarison, R; Barrett, M; Roos, C; Kappeler, P; Bielawski, J
    URI
    http://qmro.qmul.ac.uk/xmlui/handle/123456789/12307
    Collections
    • School of Biological and Chemical Sciences [1979]
    Language
    eng
    Licence information
    CC-BY
    Copyright statements
    © 2014 The Author(s)
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