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dc.contributor.authorCuzick, Jen_US
dc.contributor.authorCuschieri, Ken_US
dc.contributor.authorDenton, Ken_US
dc.contributor.authorHopkins, Men_US
dc.contributor.authorThorat, MAen_US
dc.contributor.authorWright, Cen_US
dc.contributor.authorCubie, Hen_US
dc.contributor.authorMoore, Cen_US
dc.contributor.authorKleeman, Men_US
dc.contributor.authorAustin, Jen_US
dc.contributor.authorAshdown-Barr, Len_US
dc.contributor.authorHunt, Ken_US
dc.contributor.authorCadman, Len_US
dc.date.accessioned2016-05-09T13:34:28Z
dc.date.issued2015-12-01en_US
dc.date.submitted2016-03-22T16:02:29.503Z
dc.identifier.urihttp://qmro.qmul.ac.uk/xmlui/handle/123456789/12232
dc.description.abstract© 2015 The Authors. Objectives: This study evaluated the Xpert HPV Assay in women attending screening in general practice by comparing Xpert with two established HPV tests, cytology and histology. Methods: A prospective study in women aged 20-60 years attending screening in Bristol, Edinburgh and London using residual Preservcyt cytology samples. Sample order was randomised between Roche cobas4800 and Cepheid Xpert assays with Qiagen hc2 third. Results: 3408 cases were included in the primary analysis. Positivity for Xpert was 19.6%, cobas 19.2% and hc2 19.9% with high concordance (kappa=86.8% vs cobas, 81.55 vs hc2). Xpert, cobas and hc2 showed similar sensitivity (98.7%, 97.5%, 98.7%) for CIN2+. All pairwise comparisons had high concordance (Kappa ≥0.78 with any abnormal cytology. Xpert and hc2 were positive for all cases of ≥moderate dyskaryosis ( N=63)), cobas was negative in two. Histology was available for 172 participants. 79 reported CIN2+, 47 CIN3+. All CIN3+ was positive on Xpert and hc2 and one case negative for cobas. One case of CIN2 was negative for all assays. Conclusions: The performance of Xpert HPV Assay in a general screening population is comparable to established HPV tests. It offers simplicity of testing, flexibility with non-batching of individual samples and rapid turnaround time.en_US
dc.format.extent32 - 37en_US
dc.language.isoenen_US
dc.relation.ispartofPapillomavirus Researchen_US
dc.rightsCC-BY
dc.titlePerformance of the Xpert HPV assay in women attending for cervical screeningen_US
dc.typeArticle
dc.rights.holder© 2015 The Authors
dc.identifier.doi10.1016/j.pvr.2015.05.002en_US
pubs.notesNot knownen_US
pubs.publication-statusPublisheden_US
pubs.volume1en_US


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