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    Comparative virulence of urinary and bloodstream isolates of extra-intestinal pathogenic Escherichia coli in a Galleria mellonella model 
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    • Comparative virulence of urinary and bloodstream isolates of extra-intestinal pathogenic Escherichia coli in a Galleria mellonella model
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    • Centre for Immunobiology
    • Comparative virulence of urinary and bloodstream isolates of extra-intestinal pathogenic Escherichia coli in a Galleria mellonella model
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    Comparative virulence of urinary and bloodstream isolates of extra-intestinal pathogenic Escherichia coli in a Galleria mellonella model

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    Published version (334.9Kb)
    Volume
    6
    Pagination
    145 - 151
    Publisher
    Taylor & Francis
    Journal
    Virulence
    Issue
    2
    ISSN
    2150-5608
    Metadata
    Show full item record
    Abstract
    Extra-intestinal pathogenic Escherichia coli (ExPEC) are a significant cause of urinary tract infections and bacteraemia worldwide. Currently no single virulence factor or ExPEC lineage has been identified as the sole contributor to severe extra-intestinal infection and/or urosepsis. Galleria mellonella has recently been established as a simple model for studying the comparative virulence of ExPEC. In this study we investigated the virulence of 40 well-characterized ExPEC strains, in G. mellonella, by measuring mortality (larvae survival), immune recognition/response (melanin production) and cell damage (lactate dehydrogenase production). Although mortality was similar between urinary and bloodstream isolates, it was heightened for community-associated infections, complicated UTIs and urinary-source bacteraemia. Isolates of ST131 and those possessing afa/dra, ompT and serogroup O6 were also associated with heightened virulence.
    Authors
    Ciesielczuk, H; BETTS, JW; Phee, LM; Doumith, M; Hope, R; Wordford, N; Wareham, DW
    URI
    http://qmro.qmul.ac.uk/xmlui/handle/123456789/10290
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    • Centre for Immunobiology [921]
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    Copyright © 2014 Informa UK Limited
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