Browsing Library Administration by Subject "Animals"
Now showing items 1-17 of 17
-
Alternative developmental and transcriptomic responses to host plant water limitation in a butterfly metapopulation.
(2022-11)Predicting how climate change affects biotic interactions poses a challenge. Plant-insect herbivore interactions are particularly sensitive to climate change, as climate-induced changes in plant quality cascade into the ... -
Alternative splicing in seasonal plasticity and the potential for adaptation to environmental change.
(2022-02-08)Seasonal plasticity is accomplished via tightly regulated developmental cascades that translate environmental cues into trait changes. Little is known about how alternative splicing and other posttranscriptional molecular ... -
B-cell-specific checkpoint molecules that regulate anti-tumour immunity.
(2023-07)The role of B cells in anti-tumour immunity is still debated and, accordingly, immunotherapies have focused on targeting T and natural killer cells to inhibit tumour growth1,2. Here, using high-throughput flow cytometry ... -
Biallelic CACNA2D1 loss-of-function variants cause early-onset developmental epileptic encephalopathy.
(2022-08-27)Voltage-gated calcium (CaV) channels form three subfamilies (CaV1-3). The CaV1 and CaV2 channels are heteromeric, consisting of an α1 pore-forming subunit, associated with auxiliary CaVβ and α2δ subunits. The α2δ subunits ... -
A bovine miRNA, bta-miR-154c, withstands in vitro human digestion but does not affect cell viability of colorectal human cell lines after transfection
(Wiley Open Access, 2022-03-23)Colorectal cancer (CRC) is the third most frequent human cancer with over 1.3 million new cases globally. CRC is a complex disease caused by interactions between genetic and environmental factors; in particular, high ... -
Cell-type specialization is encoded by specific chromatin topologies.
(2021-11)The three-dimensional (3D) structure of chromatin is intrinsically associated with gene regulation and cell function1-3. Methods based on chromatin conformation capture have mapped chromatin structures in neuronal systems ... -
Chickens get their place in the sun.
(BMC, 2007-05-25)A report on the International Chick Meeting 'The Chick as a Model Organism: Genes, Development and Function', Barcelona, Spain, 11-14 April 2007. -
Design of Photosensitizing Agents for Targeted Antimicrobial Photodynamic Therapy.
(2020-11-10)Photodynamic inactivation of microorganisms has gained substantial attention due to its unique mode of action, in which pathogens are unable to generate resistance, and due to the fact that it can be applied in a minimally ... -
Distinct, dosage-sensitive requirements for the autism-associated factor CHD8 during cortical development.
(2021-02-24)BACKGROUND: CHD8 haploinsufficiency causes autism and macrocephaly with high penetrance in the human population. Chd8 heterozygous mice exhibit relatively subtle brain overgrowth and little gene expression changes in the ... -
Full spectrum fluorescence lifetime imaging with 0.5 nm spectral and 50 ps temporal resolution.
(2021-11-16)The use of optical techniques to interrogate wide ranging samples from semiconductors to biological tissue for rapid analysis and diagnostics has gained wide adoption over the past decades. The desire to collect ever more ... -
Hagfish genome elucidates vertebrate whole-genome duplication events and their evolutionary consequences.
(2024-03)Polyploidy or whole-genome duplication (WGD) is a major event that drastically reshapes genome architecture and is often assumed to be causally associated with organismal innovations and radiations. The 2R hypothesis ... -
Improved chromosome-level genome assembly of the Glanville fritillary butterfly (Melitaea cinxia) integrating Pacific Biosciences long reads and a high-density linkage map.
(2022-01-12)BACKGROUND: The Glanville fritillary (Melitaea cinxia) butterfly is a model system for metapopulation dynamics research in fragmented landscapes. Here, we provide a chromosome-level assembly of the butterfly's genome ... -
Normal Somatic Mutations in Cancer Transformation.
(2021-02-08)Gene alterations play a prominent role in driving cancer initiation and progression. However, the genetic events that occur in normal cells prior to tumorigenesis are still unknown. Recent studies have started to map somatic ... -
Nutrient-Response Pathways in Healthspan and Lifespan Regulation.
(MDPI, 2022-05-06)Cellular, small invertebrate and vertebrate models are a driving force in biogerontology studies. Using various models, such as yeasts, appropriate tissue culture cells, Drosophila, the nematode Caenorhabditis elegans and ... -
Skin-resident innate lymphoid cells converge on a pathogenic effector state.
(2021-04)Tissue-resident innate lymphoid cells (ILCs) help sustain barrier function and respond to local signals. ILCs are traditionally classified as ILC1, ILC2 or ILC3 on the basis of their expression of specific transcription ... -
Transcriptomic responses to location learning by honeybee dancers are partly mirrored in the brains of dance-followers.
(The Royal Society, 2023-12-20)The waggle dances of honeybees are a strikingly complex form of animal communication that underlie the collective foraging behaviour of colonies. The mechanisms by which bees assess the locations of forage sites that they ... -
USP7 inactivation suppresses APC-mutant intestinal hyperproliferation and tumor development
(Cell Press, 2023-01-19)Adenomatous polyposis coli (APC) mutation is the hallmark of colorectal cancer (CRC), resulting in constitutive WNT activation. Despite decades of research, targeting WNT signaling in cancer remains challenging due to its ...