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The Insulin-Like Growth Factor System in the Long-Lived Naked Mole-Rat.

Brohus, M; Gorbunova, V; Faulkes, CG; Overgaard, MT; Conover, CA (2015)

Naked mole-rats (Heterocephalus glaber) (NMRs) are the longest living rodents known. They show negligible senescence, and are resistant to cancers and certain damaging effects associated with aging. The insulin-like growth ...

Inhibition of CD47 Effectively Targets Pancreatic Cancer Stem Cells via Dual Mechanisms.

Cioffi, M; Trabulo, S; Hidalgo, M; Costello, E; Greenhalf, W; Erkan, M; Kleeff, J; Sainz, B; Heeschen, C (2015-05-15)

PURPOSE: Pancreatic ductal adenocarcinoma (PDAC) is a cancer of the exocrine pancreas with unmet medical need and is strongly promoted by tumor-associated macrophages (TAM). The presence of TAMs is associated with poor ...

The Spectrin cytoskeleton regulates the Hippo signalling pathway.

Fletcher, GC; Elbediwy, A; Khanal, I; Ribeiro, PS; Tapon, N; Thompson, BJ (2015-04-01)

The Spectrin cytoskeleton is known to be polarised in epithelial cells, yet its role remains poorly understood. Here, we show that the Spectrin cytoskeleton controls Hippo signalling. In the developing Drosophila wing and ...

Astroglial Plasticity Is Implicated in Hippocampal Remodelling in Adult Rats Exposed to Antenatal Dexamethasone.

Shende, VH; McArthur, S; Gillies, GE; Opacka-Juffry, J (2015)

The long-term effects of antenatal dexamethasone treatment on brain remodelling in 3-month-old male Sprague Dawley rats whose mothers had been treated with dexamethasone were investigated in the present study. Dorsal ...