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Neurodegeneration progresses despite complete elimination of clinical relapses in a mouse model of multiple sclerosis.

Hampton, DW; Serio, A; Pryce, G; Al-Izki, S; Franklin, RJ; Giovannoni, G; Baker, D; Chandran, S (2013-12-23)

BACKGROUND: [corrected] Multiple Sclerosis has two clinical phases reflecting distinct but inter-related pathological processes: focal inflammation drives the relapse-remitting stage and neurodegeneration represents the ...

Characterization of immune response to neurofilament light in experimental autoimmune encephalomyelitis.

Puentes, F; van der Star, BJ; Victor, M; Kipp, M; Beyer, C; Peferoen-Baert, R; Ummenthum, K; Pryce, G; Gerritsen, W; Huizinga, R;... (2013)

Autoimmunity to neuronal proteins occurs in several neurological syndromes, where cellular and humoral responses are directed to surface as well as intracellular antigens. Similar to myelin autoimmunity, pathogenic immune ...