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Functional screen identifies regulators of murine hematopoietic stem cell repopulation.
Understanding the molecular regulation of hematopoietic stem and progenitor cell (HSPC) engraftment is paramount to improving transplant outcomes. To discover novel regulators of HSPC repopulation, we transplanted >1,300 ...
Lifelong haematopoiesis is established by hundreds of precursors throughout mammalian ontogeny.
Current dogma asserts that mammalian lifelong blood production is established by a small number of blood progenitors. However, this model is based on assays that require the disruption, transplantation and/or culture of ...
The global clonal complexity of the murine blood system declines throughout life and after serial transplantation.
Although many recent studies describe the emergence and prevalence of "clonal hematopoiesis of indeterminate potential" in aged human populations, a systematic analysis of the numbers of clones supporting steady-state ...
Nfix Promotes Survival of Immature Hematopoietic Cells via Regulation of c-Mpl.
Hematopoietic stem and progenitor cells (HSPCs) are necessary for life-long blood production and replenishment of the hematopoietic system during stress. We recently reported that nuclear factor I/X (Nfix) promotes HSPC ...
Murine hematopoietic stem cell activity is derived from pre-circulation embryos but not yolk sacs.
The embryonic site of definitive hematopoietic stem cell (dHSC) origination has been debated for decades. Although an intra-embryonic origin is well supported, the yolk sac (YS) contribution to adult hematopoiesis remains ...
Murine hemogenic endothelial precursors display heterogeneous hematopoietic potential ex vivo.
Hematopoietic stem and progenitor cells (HSPCs) sustain life-long hematopoiesis and are first detected in the embryo by transplantation at embryonic day 10.5 (E10.5). HSPCs are mesodermal in origin and ultimately emerge ...