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Human papilloma virus genotyping for the cross-sectional and longitudinal probability of developing cervical intraepithelial neoplasia grade 2 or more.

Del Mistro, A; Adcock, R; Carozzi, F; Gillio-Tos, A; De Marco, L; Girlando, S; Rizzolo, R; Frayle, H; Trevisan, M; Sani, C;... (2018-07-15)

Human papilloma virus (HPV) testing is more sensitive but less specific than cytology. We evaluated stand-alone genotyping as a possible triage method. During a multicentre randomised controlled trial comparing HPV testing ...

Relevance of Spatial Heterogeneity of Immune Infiltration for Predicting Risk of Recurrence After Endocrine Therapy of ER+ Breast Cancer.

Heindl, A; Sestak, I; Naidoo, K; Cuzick, J; Dowsett, M; Yuan, Y (2018-02-01)

Background: Despite increasing evidence supporting the clinical utility of immune infiltration in the estrogen receptor-negative (ER-) subtype, the prognostic value of immune infiltration for ER+ disease is not well defined. ...

Breast cancer risk in a screening cohort of Asian and white British/Irish women from Manchester UK.

Evans, DG; Brentnall, AR; Harvie, M; Astley, S; Harkness, EF; Stavrinos, P; Donnelly, LS; Sampson, S; Idries, F; Watterson, D;... (2018-01-25)

BACKGROUND: The differences between breast cancer risk factors in white British/Irish and Asian women attending screening in the UK are not well documented. METHODS: Between 2009-15 ethnicity and traditional breast cancer ...

Identification of men with low-risk biopsy-confirmed prostate cancer as candidates for active surveillance.

Lin, DW; Crawford, ED; Keane, T; Evans, B; Reid, J; Rajamani, S; Brown, K; Gutin, A; Tward, J; Scardino, P;... (2018-06)

BACKGROUND: A combined clinical cell-cycle risk (CCR) score that incorporates prognostic molecular and clinical information has been recently developed and validated to improve prostate cancer mortality (PCM) risk ...

Screening performance of abbreviated versions of the UPSIT smell test.

Joseph, T; Auger, SD; Peress, L; Rack, D; Cuzick, J; Giovannoni, G; Lees, A; Schrag, AE; Noyce, AJ (2019-08)

BACKGROUND: Hyposmia can develop with age and in neurodegenerative conditions, including Parkinson's disease (PD). The University of Pennsylvania Smell Identification Test (UPSIT) is a 40-item smell test widely used for ...

Need for expanded HPV genotyping for cervical screening.

Cuzick, J; Wheeler, C (2016-12)

The focus for HPV genotyping has largely been on types 16 and 18, based on their high prevalence in cervix cancer. However screening is focussed on the detection of high grade precursor lesions (CIN3 and CIN2), where other ...