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Clonal dynamics of haematopoiesis across the human lifespan.
(Springer Nature, 2022-06-01)
Age-related change in human haematopoiesis causes reduced regenerative capacity1, cytopenias2, immune dysfunction3 and increased risk of blood cancer4-6, but the reason for such abrupt functional decline after 70 years of ...
Clonal dynamics after allogeneic haematopoietic cell transplantation.
(Springer Nature, 2024-10-30)
Allogeneic haematopoietic cell transplantation (HCT) replaces the stem cells responsible for blood production with those from a donor1,2. Here, to quantify dynamics of long-term stem cell engraftment, we sequenced genomes ...
Analysis of somatic mutations in whole blood from 200,618 individuals identifies pervasive positive selection and novel drivers of clonal hematopoiesis.
(Springer Nature, 2024-05-14)
Human aging is marked by the emergence of a tapestry of clonal expansions in dividing tissues, particularly evident in blood as clonal hematopoiesis (CH). CH, linked to cancer risk and aging-related phenotypes, often stems ...
Identification of sixteen novel candidate genes for late onset Parkinson's disease.
(2021-06-21)
BACKGROUND: Parkinson's disease (PD) is a neurodegenerative movement disorder affecting 1-5% of the general population for which neither effective cure nor early diagnostic tools are available that could tackle the pathology ...
A PSA SNP associates with cellular function and clinical outcome in men with prostate cancer.
(Springer Nature, 2024-11-06)
Genetic variation at the 19q13.3 KLK locus is linked with prostate cancer susceptibility in men. The non-synonymous KLK3 single nucleotide polymorphism (SNP), rs17632542 (c.536 T > C; Ile163Thr-substitution in PSA) is ...
Heterogeneous association of health with patient and general practice characteristics by region, age and chronic condition: pooled cross-sectional study of patient-level data from England.
(BMJ Publishing Group, 2025-02-07)
OBJECTIVES: To investigate the association of individual patient health with their characteristics, including income deprivation, ethnicity and gender, with the size, quality and staffing of their general practices, and ...
Clinical Implications of Echocardiographic Phenotypes of Patients With Diabetes Mellitus
(Elsevier, 2017-09-25)
SARS-CoV-2 IgG Seroprevalence in the Okinawa Main Island and Remote Islands in Okinawa, Japan, 2020-2021.
(Editorial Committee of Japanese Journal of Infectious Diseases, National Institute of Infectious Disease, 2024-09-30)
We estimated the seroprevalence of anti-severe acute respiratory syndrome coronavirus 2 (anti-SARS-CoV-2) immunoglobulin G (IgG) in different island groups in Okinawa. A cross-sectional serosurvey was conducted over three ...
Sickle Cell Disorders and Severe COVID-19 Outcomes: A Cohort Study.
(American College of Physicians, 2021-07-20)