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Plasma and CSF pharmacokinetics of meropenem in neonates and young infants: results from the NeoMero studies.
(2018-07-01)
BACKGROUND: Sepsis and bacterial meningitis are major causes of mortality and morbidity in neonates and infants. Meropenem, a broad-spectrum antibiotic, is not licensed for use in neonates and infants below 3 months of age ...
Relationship Between Early Childhood Oral Health Impact Scale, Child's Dental Status and Parental Psychological Profiles.
(2022-12)
BACKGROUND: The aim of this study was to assess the influence of a child's dental status and parental psychological profiles on parental perception of their child's oral health. MATERIALS: This study involved 164 parents ...
ADAMS project: a genetic Association study in individuals from Diverse Ancestral backgrounds with Multiple Sclerosis based in the UK.
(2023-05-17)
PURPOSE: Genetic studies of multiple sclerosis (MS) susceptibility and severity have focused on populations of European ancestry. Studying MS genetics in other ancestral groups is necessary to determine the generalisability ...
Endovascular Ultrasound Renal Denervation to Treat Hypertension: The RADIANCE II Randomized Clinical Trial.
(2023-02-28)
IMPORTANCE: Two initial sham-controlled trials demonstrated that ultrasound renal denervation decreases blood pressure (BP) in patients with mild to moderate hypertension and hypertension that is resistant to treatment. ...
A blood atlas of COVID-19 defines hallmarks of disease severity and specificity.
(2022-03-03)
Treatment of severe COVID-19 is currently limited by clinical heterogeneity and incomplete description of specific immune biomarkers. We present here a comprehensive multi-omic blood atlas for patients with varying COVID-19 ...
Long-term (180-Day) Outcomes in Critically Ill Patients With COVID-19 in the REMAP-CAP Randomized Clinical Trial.
(2023-01-03)
IMPORTANCE: The longer-term effects of therapies for the treatment of critically ill patients with COVID-19 are unknown. OBJECTIVE: To determine the effect of multiple interventions for critically ill adults with COVID-19 ...
Effect of Angiotensin-Converting Enzyme Inhibitor and Angiotensin Receptor Blocker Initiation on Organ Support-Free Days in Patients Hospitalized With COVID-19: A Randomized Clinical Trial.
(2023-04-11)
IMPORTANCE: Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19. OBJECTIVE: To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin ...
Molar-incisor hypomineralisation: a prevalence study amongst primary schoolchildren of Shiraz, Iran.
(2014-04)
AIM: To investigate the prevalence of molar-incisor hypomineralisation (MIH) amongst primary schoolchildren of Shiraz, Iran, taking into account the possible influence of biographic and socio-demographic parameters. STUDY ...
Association of characteristics of delivery and medical conditions during the first month of life with developmental defects of enamel.
(2014-10-01)
BACKGROUND: Developmental defects of enamel (DDE) may be influenced by health problems and illness in children. The aim of the study was to identify the main characteristics of birth (delivery) and adverse medical conditions ...
Impact of oral clefts on the oral health-related quality of life of preschool children and their parents.
(2018-09)
OBJECTIVE: To assess the oral health-related quality of life (OHRQoL) of preschool children with cleft lip and palate (CLP) and their relatives. MATERIALS AND METHODS: In this cross-sectional study, 55 2-5-year-old children ...