Now showing items 441-446 of 446
Mechanisms of evolution in antibiotic resistant clones of Streptococcus pneumoniae
(Queen Mary University of London, 2012-12)
Streptococcus pneumoniae has a highly adaptable genome due at least in part to its natural transformability and its ability to recombine with other pneumococci and related species. The emergence of antibiotic resistant ...
Ischaemic and Pharmacological Preconditioning of the Uraemic Heart.
(Queen Mary University of London, 2011)
The incidence and mortality from cardiovascular disease (CVD) in patients with chronic kidney disease (CKD) far exceeds that seen in the general population. Whilst a number of risk factors and associations have been ...
Promoting the survival, migration and integration of Schwann cells by over-expression of polysialic acid
The poor survival and migration of transplanted Schwann cells (SCs) are major drawbacks for their clinical application in cell therapy for neurotrauma. To overcome such drawbacks we genetically modified SCs to over-express ...
Prenatal identification of trisomy 18 (Edwards syndrome)
This thesis provides a literature review of trisomy 18 (Edwards syndrome) with a focus on the use of maternal serum and ultrasound markers in the late first and early second trimester of pregnancy to aid in identifying ...
Primary tissue-based proteomic analysis of apoptosis-regulating pathways in malignant pleural mesothelioma (MPM)
Malignant pleural mesothelioma (MPM) is an aggressive and fatal malignancy associated with resistance to chemotherapy and radiotherapy. Programmed cell death or apoptosis underlies the efficacy of cytotoxic anti-cancer ...
Optimal Relaxed Designs of Experiments, with Pharmaceutical Applications
(Queen Mary University of London, 2014-06)
This thesis was motivated by the collaborative research undertaken by QMUL and Pfizer UK into improving experiments at pre-clinical drug development. In theory, the most efficient designs for these particular experiments, ...