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The chemokine receptor CXCR4 and the malignant transformation of the ovarian surface epithelium
(2010)
Ovarian cancer is the most lethal gynaecological cancer in Western world today. Mortality remains high, partly due to poor understanding of the pre-malignant changes that occur in ovarian cancers…
Apoptosis and mitotic slippage following drug intervention in leukaemia cells
(2011)
The response of leukaemia cells to therapeutic agents includes cell cycle arrest and apoptosis. The former response is useful in retarding disease progression, but induction of the latter is essential for disease eradication. ...
Design and Analysis of Multi-Arm Trials with a Common Control Using Order Restrictions
(2010)
Trials for comparing I treatments with a control are considered, where the aim is to identify
one treatment (if at least one exists) which is better than control. Tests are developed
which use all of the data simultaneously, ...
The zinc finger transcription factor Early Growth Response 2 (Egr-2) is an intrinsic regulator of T cell tolerance and homeostasis
(2009)
Tolerance of T cells to self-antigen is crucial to prevent the development of autoimmune
disease. How self-tolerance is controlled at the transcriptional level is, however,
unknown. We discovered that the transcription ...
Characterisation of immune responses to varicella vaccination in relation to clinical outcome
(2010)
This thesis examines both humoral and cellular adaptive immune responses to varicella vaccination (up to 18 months post immunisation), in an ethnically diverse population of healthcare workers. Using two parameters of ...
Role of peroxisome proliferator-activated receptor-β/δ in acute myocardial infarction, septic shock and sepsis
(2011)
Peroxisome Proliferator-Activated Receptors (PPARs) are ligand activated transcription factors that belong to the nuclear hormone receptor family. In this thesis, I have investigated the anti-inflammatory role of PPAR-β/δ ...
WNK1 and its role in hypertension
(2010)
WNK1 is a serine-threonine protein kinase involved in blood pressure (BP) control and electrolyte homeostasis. Intronic deletions in the WNK1 gene result in over-expression and lead to pseudohypoaldosteronism type II, a ...
Transcription Factor AP-2 Regulatory Signatures in Breast Cancer
(2007)
AP-2 transcription factors are highly conserved basic helix-span-helix proteins whose
members ((x, ß, y, S and c) are crucial regulators of bryonic development. They also
play an important role in human neoplasia. uohis ...
Human psychophysiological responses to visceral and somatic pain – the development of integrated, reproducible human pain phenotypes
(2011)
Background
Pain is the ubiquitous human experience, yet displays considerable inter- and intraindividual
variability in health and disease. Many factors have been proposed to
account for these differences. Pain ...
Assigning function to genome wide association study variants associated with complex gastrointestinal disease
(2009)
The genome‐wide association study era has identified numerous loci associated with many
common polygenic diseases. The next challenge is to identify the functional consequences
of these variants and elicit how they impact ...
