Now showing items 1371-1380 of 1397
Statistical cluster analysis of the British Thoracic Society Severe refractory Asthma Registry: clinical outcomes and phenotype stability.
(PLoS ONE, 2014-07-24)
BACKGROUND: Severe refractory asthma is a heterogeneous disease. We sought to determine statistical clusters from the British Thoracic Society Severe refractory Asthma Registry and to examine cluster-specific outcomes and ...
Standardisation of labial salivary gland histopathology in clinical trials in primary Sjögren's syndrome.
(BMJ Publishing Group, 2016-12-12)
Labial salivary gland (LSG) biopsy is used in the classification of primary Sjögren's syndrome (PSS) and in patient stratification in clinical trials. It may also function as a biomarker. The acquisition of tissue and ...
Informal coercion in psychiatry: a focus group study of attitudes and experiences of mental health professionals in ten countries.
Purpose: Whilst formal coercion in psychiatry is regulated by legislation, other interventions that are often referred to as informal coercion are less regulated. It remains unclear to what extent these interventions ...
Inhibitory member of the apoptosis-stimulating proteins of the p53 family (iASPP) interacts with protein phosphatase 1 via a noncanonical binding motif.
Although kinase mutations have been identified in various human diseases, much less is known about protein phosphatases. Here, we show that all apoptosis-stimulating proteins of p53 (ASPP) family members can bind protein ...
Maternal 25-hydroxyvitamin D and its association with childhood atopic outcomes and lung function.
BACKGROUND: It has been suggested that maternal vitamin D status in pregnancy influences the risk of asthma and atopy in the offspring. The epidemiological evidence to support these claims is conflicting and may reflect ...
Myocardial tissue phase mapping reveals impaired myocardial tissue velocities in obesity.
Although obesity is linked to heart failure on a population level, not all obese subjects develop cardiac failure. As a result, identifying obese subjects with subclinical changes in myocardial velocities may enable earlier ...
Testing the Penrose Hypothesis-Reply.
Neurofilament light chain: A prognostic biomarker in amyotrophic lateral sclerosis.
OBJECTIVE: To test blood and CSF neurofilament light chain (NfL) levels in relation to disease progression and survival in amyotrophic lateral sclerosis (ALS). METHODS: Using an electrochemiluminescence immunoassay, NfL ...
24-h urinary sodium excretion is associated with obesity in a cross-sectional sample of Australian schoolchildren.
(Cambridge University Press, 2016-01-26)
Emerging evidence indicates that dietary Na may be linked to obesity; however it is unclear whether this relationship is independent of energy intake (EI). The aim of this study was to assess the association between Na ...
Doppler ultrasound signal in Achilles tendinopathy reduces immediately after activity.
BACKGROUND: A relationship has been identified between vascularization on Doppler ultrasound (Doppler signal) and Achilles tendon pain. Doppler signal may increase minutes after prolonged activity, but the immediate effect ...