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T-cell reconstitution after thymus xenotransplantation induces hair depigmentation and loss.
(2013-05)
Here we present a mouse model for T-cell targeting of hair follicles, linking the pathogenesis of alopecia to that of depigmentation disorders. Clinically, thymus transplantation has been successfully used to treat T-cell ...
Motor-commands decoding using peripheral nerve signals: a review.
(2018-06)
During the last few decades, substantial scientific and technological efforts have been focused on the development of neuroprostheses. The major emphasis has been on techniques for connecting the human nervous system with ...
Pleiotropic Role and Bidirectional Immunomodulation of Innate Lymphoid Cells in Cancer.
(2019)
Innate lymphoid cells (ILCs) are largely tissue resident and respond rapidly toward the environmental signals from surrounding tissues and other immune cells. The pleiotropic function of ILCs in diverse contexts underpins ...
Hematopoietic stem cells under pressure.
(2017-07)
PURPOSE OF REVIEW: Hematopoietic stem cells (HSCs) and progenitors are tasked with maintaining hematopoietic homeostasis in the face of numerous insults and challenges, including infection, inflammation, and exsanguination. ...
T-cell number and subtype influence the disease course of primary chronic lymphocytic leukaemia xenografts in alymphoid mice.
(2015-11)
Chronic lymphocytic leukaemia (CLL) cells require microenvironmental support for their proliferation. This can be recapitulated in highly immunocompromised hosts in the presence of T cells and other supporting cells. Current ...
Melanocortin peptide therapy for the treatment of arthritic pathologies.
(2009-12-16)
Arthritic pathologies are a major cause of morbidity within the western world, with rheumatoid arthritis affecting approximately 1% of adults. This review highlights the therapeutic potential of naturally occurring hormones ...
ITPase deficiency causes a Martsolf-like syndrome with a lethal infantile dilated cardiomyopathy.
(2019-03)
Typical Martsolf syndrome is characterized by congenital cataracts, postnatal microcephaly, developmental delay, hypotonia, short stature and biallelic hypomorphic mutations in either RAB3GAP1 or RAB3GAP2. Genetic analysis ...
Phagocytosis is the main CR3-mediated function affected by the lupus-associated variant of CD11b in human myeloid cells.
(2013)
The CD11b/CD18 integrin (complement receptor 3, CR3) is a surface receptor on monocytes, neutrophils, macrophages and dendritic cells that plays a crucial role in several immunological processes including leukocyte ...
THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein-coupled receptors.
(2019-12)
The Concise Guide to PHARMACOLOGY 2019/20 is the fourth in this series of biennial publications. The Concise Guide provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on ...
Evaluation of a novel non-destructive catch and release technology for harvesting autologous adult stem cells.
(Public Library of Science, 2013-01-22)
BACKGROUND: Cell based therapies are required now to meet the critical care needs of paediatrics and healthy ageing in an increasingly long-lived human population. Repair of compromised tissue by supporting autologous ...