Now showing items 1-3 of 3
QTL mapping of Apc modifiers in an ApcMin/+ mouse model of spontaneous and irradiation-induced intestinal adenomas.
(Queen Mary University of London, 2013)
BACKGROUND: Radiation exposure to the abdominal region causes intestinal toxicity and is also capable of inducing colorectal cancers (CRC). Genotype-phenotype studies provide some evidence explaining the variation in ...
Identification of novel therapeutics for the treatment of MMR deficient tumours using high-throughput screens.
(Queen Mary University of London, 2015-05)
The DNA Mismatch repair (MMR) pathway is responsible for the repair of base-base mismatches and insertion/deletion loops, formed during DNA replication. Mutations in MMR genes significantly increase the predisposition to ...
The role of PROM-1/CD/AC133 in colorectal cancer.
(Queen Mary University of London, 2012)
Background: Colorectal cancer is the result of dysregulation within classic regulatory pathways in epithelial stem-cell(s): the precursors giving rise to all other intestinal lineages. The resulting cancer stem-cell (CSC) ...