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Parkinson's disease in GTP cyclohydrolase 1 mutation carriers.
(2014-09)
GTP cyclohydrolase 1, encoded by the GCH1 gene, is an essential enzyme for dopamine production in nigrostriatal cells. Loss-of-function mutations in GCH1 result in severe reduction of dopamine synthesis in nigrostriatal ...
Clinical picture and treatment of 2212 patients with common variable immunodeficiency.
(Elsevier, 2014-02-28)
BACKGROUND: Common variable immunodeficiency (CVID) is an antibody deficiency with an equal sex distribution and a high variability in clinical presentation. The main features include respiratory tract infections and their ...
Cytokine responses to the anti-schistosome vaccine candidate antigen glutathione-S-transferase vary with host age and are boosted by praziquantel treatment.
(Public Library of Science, 2014-05-08)
BACKGROUND: Improved helminth control is required to alleviate the global burden of schistosomiasis and schistosome-associated pathologies. Current control efforts rely on the anti-helminthic drug praziquantel (PZQ), which ...
Circulating CD14brightCD16+ 'intermediate' monocytes exhibit enhanced parasite pattern recognition in human helminth infection.
(Public Library of Science, 2014-04-24)
Circulating monocyte sub-sets have recently emerged as mediators of divergent immune functions during infectious disease but their role in helminth infection has not been investigated. In this study we evaluated whether ...
NF-κB activation and severity of gastritis in Helicobacter pylori-infected children and adults.
(2014-06)
BACKGROUND: In contrast to adults, Helicobacter pylori gastritis in children is reported as milder and ulcer disease as uncommon, but unequivocal data are lacking. OBJECTIVES: To compare the frequency of gastro-duodenal ...
Molar-incisor hypomineralisation: a prevalence study amongst primary schoolchildren of Shiraz, Iran.
(2014-04)
AIM: To investigate the prevalence of molar-incisor hypomineralisation (MIH) amongst primary schoolchildren of Shiraz, Iran, taking into account the possible influence of biographic and socio-demographic parameters. STUDY ...
Association of characteristics of delivery and medical conditions during the first month of life with developmental defects of enamel.
(2014-10-01)
BACKGROUND: Developmental defects of enamel (DDE) may be influenced by health problems and illness in children. The aim of the study was to identify the main characteristics of birth (delivery) and adverse medical conditions ...
Socioeconomic inequalities in dental caries and their determinants in adolescents in New Delhi, India
(BMJ Publishing Group, 2014-12-12)
OBJECTIVES: To determine whether socioeconomic inequalities are correlated to dental caries experience and decayed teeth of Indian adolescents, and assess whether behavioural and psychosocial factors mediate this association. ...