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SETDB1 prevents TET2-dependent activation of IAP retroelements in naïve embryonic stem cells.
BACKGROUND: Endogenous retroviruses (ERVs), which are responsible for 10% of spontaneous mouse mutations, are kept under control via several epigenetic mechanisms. The H3K9 histone methyltransferase SETDB1 is essential for ...
Profiling DNA Methylation and Hydroxymethylation at Retrotransposable Elements.
DNA methylation is a key epigenetic modification controlling the transcriptional activity of mammalian retrotransposable elements. Its oxidation to DNA hydroxymethylation has been linked to DNA demethylation and reactivation ...