Now showing items 1-4 of 4
QTL mapping of Apc modifiers in an ApcMin/+ mouse model of spontaneous and irradiation-induced intestinal adenomas.
(Queen Mary University of London, 2013)
BACKGROUND: Radiation exposure to the abdominal region causes intestinal toxicity and is also capable of inducing colorectal cancers (CRC). Genotype-phenotype studies provide some evidence explaining the variation in ...
Identification of novel therapeutics for the treatment of MMR deficient tumours using high-throughput screens.
(Queen Mary University of London, 2015-05)
The DNA Mismatch repair (MMR) pathway is responsible for the repair of base-base mismatches and insertion/deletion loops, formed during DNA replication. Mutations in MMR genes significantly increase the predisposition to ...
Exploring stem cell dynamics, clonal expansion and pseudopolyps in inflammatory bowel disease.
(Queen Mary University of London, 2015)
Inflammatory bowel disease (IBD) confers a high risk of development of colitis-associated colorectal cancer in patients with extensive colitis. Crypt fission is a mechanism of clonal expansion in the intestinal epithelium. ...
The role of PROM-1/CD/AC133 in colorectal cancer.
(Queen Mary University of London, 2012)
Background: Colorectal cancer is the result of dysregulation within classic regulatory pathways in epithelial stem-cell(s): the precursors giving rise to all other intestinal lineages. The resulting cancer stem-cell (CSC) ...