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Targeting the Unfolded Protein Response as a Novel Therapeutic Approach in Haematological Malignancies
(Queen Mary University of London, 2012-04)
The unfolded protein response (UPR) is a complex signalling pathway activated in response
to endoplasmic reticulum stress. In recent years, the UPR has been implicated in cancer and
chemosensitivity, particularly in solid ...
Structure and Function Analysis of the Mammalian ATP-Binding Cassette Transporters, ABCB1 and ABCB4.
(Queen Mary University of London, 2012-09)
Mammalian ABC (ATP-binding cassette) transporters are integral membrane proteins that translocate allocrites across biological membranes using ATP as a substrate.
ABCB1 is a polyspecific efflux pump which can confer ...
Investigating the functional significance of an FGFR2 intronic SNP in Breast Cancer
(Queen Mary University of London, 2013-05)
Single nucleotide polymorphisms present in the second intron of the fibroblast growth factor receptor 2 (FGFR2) gene have been linked with increased risk of breast cancer in several genome wide association studies. The ...
The Development and Characterisation of Peptides to Image αvβ6 in Cancer.
(Queen Mary University of London, 2011-01)
Introduction The epithelial-specific integrin αvβ6 usually is undetectable on normal, adult, human tissue but is upregulated during tissue re-modelling and carcinogenesis.
Objective To develop and characterise agents for ...
Studying the role of integrin αVβ6 in pancreatic cancer
(Queen Mary University of London, 2013-01)
Pancreatic cancer is often referred to as the “silent killer“ due to the asymptomatic
nature of the disease in the early stages and the extremely poor prognosis overall.
The average one-year survival rate for PDAC patients ...
Identification of novel therapeutics for the treatment of MMR deficient tumours using high-throughput screens.
(Queen Mary University of London, 2015-05)
The DNA Mismatch repair (MMR) pathway is responsible for the repair of base-base mismatches and insertion/deletion loops, formed during DNA replication. Mutations in MMR genes significantly increase the predisposition to ...
The role of epithelial cell-derived tumour necrosis Factor Alpha in pancreatic carcinogenesis
(Queen Mary University of London, 2012-03)
Activating mutations of the kras proto-oncogene are found in more than 90 % of
human pancreatic ductal adenocarcinoma (PDAC) and can result in increased
activity of the NF-κB pathway, leading to constitutive production ...
Desmoplastic stromal cells modulate tumour cell behaviour in pancreatic cancer
(Queen Mary University of London, 2013-01)
Pancreatic
ductal
adenocarcinoma
(PDAC)
is
characterised
by
an
intense
desmoplastic
stromal
response
that
can
comprise
60
to
80%
of
tumour
volume
and
has
been
implicated
to
be
a
factor
in
pr ...
The Subcellular Localisation of HAX1 Isoforms and Their Roles in Cancer Cell Migration, Autophagy and Apoptosis.
(Queen Mary University of London, 2013-02)
It has been reported that HAX1 is a multi-functional protein which protects cells from apoptosis, modulates autophagy, regulates membrane protein trafficking and promotes cell migration. Many studies have shown it has many ...
Strengthening grassroots organisations for forest management: the case of induced forest-based grassroots groups in Quang Tri Province, Vietnam
(Queen Mary University of London, 2012)
Academic and public policy interest in the role of local resource users in the management of
forests has grown in recent decades. While much attention has focused on the self-organisation
of user groups, with autonomy ...
