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DNA methylation profiles between airway epithelium and proxy tissues in children.

Brugha, R; Lowe, R; Henderson, AJ; Holloway, JW; Rakyan, V; Wozniak, E; Mahmud, N; Seymour, K; Grigg, J; Shaheen, SO (2017-12)

AIM: Epidemiological studies of deoxyribonucleic acid (DNA) methylation in airway disease have largely been conducted using blood or buccal samples. However, given tissue specificity of DNA methylation, these surrogate ...

Carbonaceous particulate matter on the lung surface from adults living in São Paulo, Brazil.

Padovan, MG; Whitehouse, A; Gouveia, N; Habermann, M; Grigg, J (2017)

OBJECTIVES: We therefore sought to identify the exposures associated with lung surface in long-term residents of São Paulo, Brazil. METHODS: Lung surface carbon were analyzed in 72 autopsy specimens by image analysis. ...

Increased Dose of Inhaled Corticosteroid versus Add-On Long-acting β-Agonist for Step-Up Therapy in Asthma.

Israel, E; Roche, N; Martin, RJ; Colice, G; Dorinsky, PM; Postma, DS; Guilbert, TW; van Aalderen, WMC; Grigg, J; Hillyer, EV;... (2015-06)

RATIONALE: Guidelines advocate adding long-acting β-agonist (LABA) to inhaled corticosteroid as the preferred step-up therapy to increasing inhaled corticosteroid dose for patients with uncontrolled asthma on inhaled ...

Local action on outdoor air pollution to improve public health.

Vardoulakis, S; Kettle, R; Cosford, P; Lincoln, P; Holgate, S; Grigg, J; Kelly, F; Pencheon, D (2018-06)

OBJECTIVES: The National Institute for Health and Care Excellence, jointly with Public Health England, have developed a guideline on outdoor air pollution and its links to health. The guideline makes recommendations on ...

Asthma control in London secondary school children.

Harris, K; Mosler, G; Williams, SA; Whitehouse, A; Raine, R; Grigg, J (2017-12)

OBJECTIVE: The asthma control test (ACT) is a validated tool for assessing control in asthmatic children aged 12 years and older. Using the ACT, we sought to assess asthma control and knowledge in London secondary school ...

Reply.

Oliver, AJ; Goldfrad, CH; Tomkins, SA; Grigg, J (2017-07)

Air Pollution and Respiratory Infection: An Emerging and Troubling Association.

Grigg, J (2018-09-15)

Extrafine Versus Fine Inhaled Corticosteroids in Relation to Asthma Control: A Systematic Review and Meta-Analysis of Observational Real-Life Studies.

Sonnappa, S; McQueen, B; Postma, DS; Martin, RJ; Roche, N; Grigg, J; Guilbert, T; Gouder, C; Pizzichini, E; Niimi, A;... (2018-05)

BACKGROUND: The particle size of inhaled corticosteroids (ICSs) may affect airway drug deposition and effectiveness. OBJECTIVE: To compare the effectiveness of extrafine ICSs (mass median aerodynamic diameter, <2 μm) versus ...

The Severe Paediatric Asthma Collaborative in Europe (SPACE) ERS Clinical Research Collaboration: enhancing participation of children with asthma in therapeutic trials of new biologics and receptor blockers.

Rusconi, F; Fernandes, RM; Pijnenburg, MWH; Grigg, J; SPACE Clinical Research Collaboration; European Lung Foundation severe asthma patient advisory group (2018-10)

Preschool wheeze, genes and treatment.

Nwokoro, C; Grigg, J (2018-09)

Preschool wheeze is a common but poorly understood cause of respiratory morbidity that is both distinct from and overlaps with infantile bronchiolitis and school age asthma. Attempts at classification by epidemiology, ...