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Inactive or moderately active human promoters are enriched for inter-individual epialleles.
(2013-05-25)
BACKGROUND: Inter-individual epigenetic variation, due to genetic, environmental or random influences, is observed in many eukaryotic species. In mammals, however, the molecular nature of epiallelic variation has been ...
Month of birth and thymic output.
(2013-04)
Hypovitaminosis-D and EBV: no interdependence between two MS risk factors in a healthy young UK autumn cohort.
(2014-05)
Late Epstein-Barr virus infection and hypovitaminosis-D as environmental risk factors in the pathogenesis of multiple sclerosis are gaining great interest. We, therefore, tested for in-vivo interdependence between ...
Atraumatic needles for lumbar puncture: why haven't neurologists changed?
(2015-08-05)
Diagnostic lumbar puncture is a key procedure in neurology; however, it is commonly complicated by post-lumbar puncture headache. Atraumatic needle systems can dramatically reduce the incidence of this iatrogenic complication. ...
Is it time to target no evident disease activity (NEDA) in multiple sclerosis?
(2015-07)
The management of multiple sclerosis is becoming increasingly complex with the emergence of new and more effective disease-modifying therapies (DMT). We propose a new treatment paradigm that individualises treatment based ...
The role of infections in Behçet disease and neuro-Behçet syndrome.
(2015-03-11)
Infections are considered an environmental trigger for exacerbations of immune-mediated diseases. We aimed to establish if common viral infections could be identified as a precipitant of Behçet disease (BD) with or without ...
Disposable MMP-9 sensor based on the degradation of peptide cross-linked hydrogel films using electrochemical impedance spectroscopy.
(2015-01-26)
Matrix metalloproteinase-9 (MMP-9) plays an important role in both physiological and pathological processes. This enzyme is a peripheral biomarker of neuroinflammation in multiple sclerosis (MS), a chronic autoimmune disease ...
Disease modifying drugs in multiple sclerosis: mechanisms of action and new drugs in the horizon.
(2012-08-01)
The term "disease modifying drugs" (DMD) is taken from rheumatologists who coined it after the use of immunosuppressive drugs and, more recently, the association of "biological drugs" that changed the degenerative course ...
Month of birth, vitamin D and risk of immune-mediated disease: a case control study.
(2012-07-06)
BACKGROUND: A season of birth effect in immune-mediated diseases (ID) such as multiple sclerosis and type 1 diabetes has been consistently reported. We aimed to investigate whether season of birth influences the risk of ...
Myasthenia gravis and neuromyelitis optica spectrum disorder: a multicenter study of 16 patients.
(2012-05-15)
OBJECTIVE: To describe 16 patients with a coincidence of 2 rare diseases: aquaporin-4 antibody (AQP4-Ab)-mediated neuromyelitis optica spectrum disorder (AQP4-NMOSD) and acetylcholine receptor antibody (AChR-Ab)-mediated ...
