Now showing items 1-5 of 5
Monocyte gene-expression profiles associated with childhood-onset type 1 diabetes and disease risk: a study of identical twins.
OBJECTIVE: Monocytes in childhood-onset type 1 diabetes show distinct gene expression. We hypothesize that monocyte activation in monozygotic (MZ) twin pairs discordant for childhood-onset type 1 diabetes could reflect ...
Glycotoxin and autoantibodies are additive environmentally determined predictors of type 1 diabetes: a twin and population study.
In type 1 diabetes, diabetes-associated autoantibodies, including islet cell antibodies (ICAs), reflect adaptive immunity, while increased serum N(ε)-carboxymethyl-lysine (CML), an advanced glycation end product, is ...
Genetic risk scores in adult-onset type 1 diabetes.
First Genome-Wide Association Study of Latent Autoimmune Diabetes in Adults Reveals Novel Insights Linking Immune and Metabolic Diabetes.
(American Diabetes Association, 2018-09-25)
OBJECTIVE: Latent autoimmune diabetes in adults (LADA) shares clinical features with both type 1 and type 2 diabetes; however, there is ongoing debate regarding the precise definition of LADA. Understanding its genetic ...