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The potential therapeutic role of selenium in diffuse large B-cell lymphoma
(2011)
The clinical background to this work confirms the very poor outcome of patients with recurrent diffuse large B-cell lymphoma (DLBCL) and highlights the need for better therapies. One such potential option would be to add ...
DNA methylation in follicular lymphoma
(2010)
Follicular Lymphoma (FL) is a common B cell Non-Hodgkin Lymphoma with a median survival of 8-10 years. Patients frequently undergo transformation to a more aggressive lymphoma and this is associated with drastically reduced ...
Pharmacokinetic studies of drug absorption into human skin
(2010)
Optimum therapeutic outcomes require not only proper drug selection but also effective
drug delivery and monitoring. The aim of this thesis was to A) study drug delivery
through the skin with a liquid formulated to ...
Systematic analysis of genomic alterations in prostate cancer
(2011)
Prostate cancer is the most common male cancer in Western countries. The genetic
mechanism underlying its initiation and progression is still unclear. The aim of this
project was to identify novel genomic changes in ...
Phylo-epidemiological and pathogenic diversity of Mycobacterium tuberculosis strains in London with implications for vaccine develpoment
(2010)
Approximately one-third of the global population is infected with tuberculosis causing
approximately 1.7 million deaths. Currently, the BCG vaccine is used to protect
against TB, but it cannot prevent primary infection ...
Molecular genetic analysis in the hereditary vitreoretinopathies
(2010)
‘Hereditary vitreoretinopathy’ encompasses a group of inherited disorders characterized by an abnormal appearance to the vitreous gel of the eye. These conditions have a reputation among ophthalmologists for consisting ...
The effects of parenteral or dietary omega-3 polyunsaturated fatty acids in rat models of spinal cord injury
(2010)
There is currently no effective treatment for spinal cord injury (SCI). Long chain omega-3 polyunsaturated fatty acids (PUFA) such as docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) have beneficial effects in ...
Trafficking and signalling of oncogenic met
(2010)
The Receptor Tyrosine Kinase (RTK) Met influences behaviour of several
cancers by controlling growth, survival and metastasis. Recently,
compartmentalisation of signals generated by RTKs, due to their
endocytosis / ...
Studies on the behaviour of human pancreatic carcinoma cell lines, with particular reference to stem cells
(2010)
Stem cell therapy represents a potential -cell replacement strategy in diabetes and a
pancreatic cancer (PC) stem cell is an attractive therapeutic target in this dire disease.
However, a normal stem cell remains ...
Investigating the roles of the alternative Isoforms of the preTCR alpha (pTα) chain in T cell development
(2010)
The pre-T cell receptor (preTCR) is required for αβ T cell development and hence efficient adaptive immunity. Composed of a rearranged TCRβ chain paired with the invariant preTCR α chain (pTα), it drives immature thymocytes ...
