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Re-designing Interleukin-12 to enhance its safety and potential as an anti-tumor immunotherapeutic agent.

Wang, P; Li, X; Wang, J; Gao, D; Li, Y; Li, H; Chu, Y; Zhang, Z; Liu, H; Jiang, G;... (2017-11-09)

Interleukin-12 (IL-12) has emerged as one of the most potent agents for anti-tumor immunotherapy. However, potentially lethal toxicity associated with systemic administration of IL-12 precludes its clinical application. ...