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WS01b: Self and Non-Self: A History of Autoimmunity (14-Feb-1995)
Selection of photos taken at the Witness Seminar “Self and Non-Self: A History of Autoimmunity” held by the History of Twentieth Century Medicine Group, 14-Feb-1995. Participants: Professor J Richard Batchelor, Sir Christopher ...
Human CD8+ EMRA T cells display a senescence-associated secretory phenotype regulated by p38 MAPK.
Cellular senescence is accompanied by a senescence-associated secretory phenotype (SASP). We show here that primary human senescent CD8+ T cells also display a SASP comprising chemokines, cytokines and extracellular matrix ...
Mitochondrial mass governs the extent of human T cell senescence
(Wiley Online, 2019-12-02)
The susceptibility of human CD4+ and CD8+ T cells to senesce differs, with CD8+ T cells acquiring an immunosenescent phenotype faster than the CD4+ T cell compartment. We show here that it is the inherent difference in ...