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Dynamics and genomic landscape of CD8+ T cells undergoing hepatic priming.
(2019-10)
The responses of CD8+ T cells to hepatotropic viruses such as hepatitis B range from dysfunction to differentiation into effector cells, but the mechanisms that underlie these distinct outcomes remain poorly understood. ...
Loss of transcriptional control over endogenous retroelements during reprogramming to pluripotency.
(2014-05-30)
Endogenous retroelements (EREs) account for about half of the mouse or human genome, and their potential as insertional mutagens and transcriptional perturbators is suppressed by early embryonic epigenetic silencing. Here, ...