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Small molecule chemokine mimetics suggest a molecular basis for the observation that CXCL10 and CXCL11 are allosteric ligands of CXCR3.

Nedjai, B; Li, H; Stroke, IL; Wise, EL; Webb, ML; Merritt, JR; Henderson, I; Klon, AE; Cole, AG; Horuk, R;... (2012-06)

BACKGROUND AND PURPOSE: The chemokine receptor CXCR3 directs migration of T-cells in response to the ligands CXCL9/Mig, CXCL10/IP-10 and CXCL11/I-TAC. Both ligands and receptors are implicated in the pathogenesis of ...