Browsing by Subject "NAD"
Now showing items 1-4 of 4
-
Replicatively senescent human fibroblasts reveal a distinct intracellular metabolic profile with alterations in NAD+ and nicotinamide metabolism.
(2016-12-07)Cellular senescence occurs by proliferative exhaustion (PEsen) or following multiple cellular stresses but had not previously been subject to detailed metabolomic analysis. Therefore, we compared PEsen fibroblasts with ... -
Structural basis for a complex I mutation that blocks pathological ROS production.
(2021-01-29)Mitochondrial complex I is central to the pathological reactive oxygen species (ROS) production that underlies cardiac ischemia-reperfusion (IR) injury. ND6-P25L mice are homoplasmic for a disease-causing mtDNA point ... -
Targeting the substrate preference of a type I nitroreductase to develop antitrypanosomal quinone-based prodrugs.
(2012-11)Nitroheterocyclic prodrugs are used to treat infections caused by Trypanosoma cruzi and Trypanosoma brucei. A key component in selectivity involves a specific activation step mediated by a protein homologous with type I ...