Browsing by Author "Yachnin, J"

Now showing items 1-3 of 3

Androgen Receptor Burden and Poor Response to Abiraterone or Enzalutamide in TP53 Wild-Type Metastatic Castration-Resistant Prostate Cancer

De Laere, B; Rajan, P; Gronberg, H; Dirix, L; Lindberg, J; Mayrhofer, M; Whitington, T; van Dam, P-J; Van Oyen, P; Ghysel, C (2019-07)
Cell-free DNA profiling of metastatic prostate cancer reveals microsatellite instability, structural rearrangements and clonal hematopoiesis.

Mayrhofer, M; De Laere, B; Whitington, T; Van Oyen, P; Ghysel, C; Ampe, J; Ost, P; Demey, W; Hoekx, L; Schrijvers, D (BioMed Central, 2018-11-21)

BACKGROUND: There are multiple existing and emerging therapeutic avenues for metastatic prostate cancer, with a common denominator, which is the need for predictive biomarkers. Circulating tumor DNA (ctDNA) has the potential ...
TP53 outperforms other androgen receptor biomarkers to predict abiraterone or enzalutamide outcome in metastatic castration-resistant prostate cancer.

De Laere, B; Oeyen, S; Mayrhofer, M; Whitington, T; van Dam, P-J; Van Oyen, P; Ghysel, C; Ampe, J; Ost, P; Demey, W (2018-09-12)

PURPOSE: To infer the prognostic value of simultaneous androgen receptor (AR) and TP53 profiling in liquid biopsies from metastatic castration-resistant prostate cancer (mCRPC) patients starting a new line of AR signalling ...