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Q
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q
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B*
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BT
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(COMMENTARY) Tj
/F2 1 Tf
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[(Venous) -300.700012207 (congestion:) -306.700012207 (are) -300.299987793 (we) -300.200012207 (adding) -301.5 (insult) -300.6000061035 (to) ] TJ
0 -1.0842000246 TD
[(kidney) -301.799987793 (injury) -302.1000061035 (in) -300.6000061035 (sepsis?) ] TJ
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10.4498996735 0 0 11.0001001358 56.6929016113 602.7022094727 Tm
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(2*) Tj
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[(et) -299.200012207 (al) ] TJ
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1.7070000172 0 TD
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(Abstract) Tj
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T*
[(Traditional) -278.3999938965 (approaches) -278 (to) -272.5 (prevention) -274.8999938965 (of) -274.799987793 (organ) ] TJ
0 -1.1962000132 TD
[(dysfunction) -276 (in) -270.1000061035 (ear) -7.5999999046 (ly) -267.799987793 (sepsis) -276.6000061035 (have) -273 (focus) -8.3000001907 (ed) -266.8999938965 (on) -276 (prevention) ] TJ
0 -1.2019000053 TD
[(of) -269.200012207 (hypoperfus) -12.1000003815 (ion) -272.1000061035 (by) -269.200012207 (optimisat) -9.8000001907 (ion) -272.1000061035 (of) -269.200012207 (systemic) ] TJ
T*
[(haemodynamic) -12 (s,) -269.3999938965 (primarily) -276.1000061035 (by) -274.8999938965 (fluid) -275.6000061035 (resuscitation.) -281.299987793 (Fluid) ] TJ
0 -1.1962000132 TD
[(administration) -280.8999938965 (to) -272.5 (a) -267.299987793 (target) -274.200012207 (central) -275.700012207 (veno) -7.5999999046 (us) -272.5 (pressure) ] TJ
0 -1.2019000053 TD
[(\(CVP\)) -270.799987793 (of) -274.799987793 (8) -269.299987793 (t) 0 (o) -266.799987793 (1) 0 (2) -272.200012207 (mmH) -7.4000000954 (g) -269.700012207 (\(12) -273 (to) -266.799987793 (15) -272.200012207 (mmHg) -277.1000061035 (in) ] TJ
T*
[(mechanically) -277.6000061035 (ventilate) -10 (d) -269.700012207 (patients\)) -273.799987793 (is) -272.700012207 (currently) ] TJ
0 -1.1962000132 TD
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0 -1.2019000053 TD
[(shock.) -270.6000061035 (Ho) -6.1999998093 (wever,) -271.700012207 (in) -275.799987793 (the) -269.700012207 (previous) -275.700012207 (issue) -276 (of) ] TJ
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16.2537994385 0 TD
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/F3 1 Tf
4.597799778 0 TD
(,) Tj
-20.8514995575 -1.2019000053 TD
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0 -1.1962000132 TD
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0 -1.2019000053 TD
[(associated) -279.3999938965 (with) -270.6000061035 (increased) -276.6000061035 (risk) -274.3999938965 (for) -273 (developm) -9.8999996185 (ent) -269.700012207 (or) ] TJ
T*
[(persistence) -275.8999938965 (of) -274.799987793 (AKI) -267.700012207 (over) -276 (the) -269.700012207 (next) -273.6000061035 (5) -269.299987793 (days.) -278.700012207 (This) -270.200012207 (study) ] TJ
0 -1.1962000132 TD
[(highlights) -275.700012207 (a) -273 (potential) -272.200012207 (associat) -12.5 (ion) -266.3999938965 (betwe) -9.5 (en) -271.299987793 (venous) ] TJ
0 -1.2019000053 TD
[(congestion) -273.200012207 (and) -278.200012207 (the) -269.700012207 (development) -279.700012207 (of) -269.200012207 (septic) -276.8999938965 (AKI,) ] TJ
T*
[(suggesting) -274.8999938965 (th) -6.0999999046 (at) -271.5 (CVP-targeted) -275.6000061035 (fluid) -275.6000061035 (resuscitat) -10.8000001907 (ion) -272.1000061035 (in) ] TJ
0 -1.1962000132 TD
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/F5 1 Tf
9.7999000549 0 0 9.7999000549 56.6929016113 278.1921081543 Tm
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0 -1.2264000177 TD
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T*
[(intern) -8.5 (ationally.) -513.299987793 (Despite) -506.200012207 (adva) -8.6999998093 (nces) -506.200012207 (in) -501.200012207 (our) -507.799987793 (understandin) -12.3999996185 (g) ] TJ
0 -1.220600009 TD
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0 -1.2264000177 TD
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T*
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0 -1.220600009 TD
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T*
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0 -1.2264000177 TD
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(2) Tj
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-0.3553000093 -1.2019000053 TD
[(Whitechapel) -308.799987793 (Road,) -301.8999938965 (London) -304.700012207 (E1) -302.700012207 (1BB,) -305.200012207 (UK) ] TJ
T*
[(Full) -306.799987793 (list) -301.299987793 (of) -297.5 (author) -303.3999938965 (informa) -11.6999998093 (tion) -302.700012207 (is) -297.299987793 (available) -309.700012207 (at) -301.700012207 (the) -305.700012207 (end) -301 (of) -297.5 (the) -305.6000061035 (article) ] TJ
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T*
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T*
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T*
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0 -1.2264000177 TD
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T*
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0 -1.220600009 TD
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T*
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T*
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0 -1.2264000177 TD
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T*
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0 -1.220600009 TD
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0 -1.2264000177 TD
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T*
[(resuscita) -12.5 (tion) -388.1000061035 (is) -384.700012207 (to) -390.200012207 (ensur) -8.3000001907 (e) ] TJ
/F7 1 Tf
11.0668001175 0 TD
<91> Tj
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<92> Tj
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0 -1.2264000177 TD
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T*
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0 -1.220600009 TD
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0 -1.2264000177 TD
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T*
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0 -1.220600009 TD
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T*
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0 -1.220600009 TD
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-1.4980000257 -2.2409999371 -0.7599999905 -1.4670000076 -0.5099999905 -0.4539999962 c
-0.5099999905 0 l
B*
Q
q
1 0 0 1 535.5780029297 439.1430053711 cm
0 0 m
-227.8489990234 0 l
-227.8489990234 0.5099999905 l
0 0.5099999905 l
B*
Q
q
1 0 0 1 307.7290039062 439.1430053711 cm
0 0 m
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-1.6469999552 0.1389999986 -2.8469998837 1.3630000353 -2.9479999542 2.4949998856 c
-3.0050001144 3.0050001144 l
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-2.382999897 1.6039999723 -1.3819999695 0.6999999881 -0.4539999962 0.5669999719 c
0 0.5099999905 l
B*
Q
q
1 0 0 1 304.7239990234 442.1480102539 cm
0 0 m
0 2.493999958 l
0.5099999905 2.493999958 l
0.5099999905 0 l
B*
Q
BT
/F5 1 Tf
9.7999000549 0 0 9.7999000549 56.6929016113 696.92578125 Tm
0 0 0 1 k
0 Tc
0 Tw
[(renal) -562.799987793 (venou) -10.1000003815 (s) -558 (congestion) -566.4000244141 (can) -561.4000244141 (redu) -9.3000001907 (ce) -558 (renal) -562.799987793 (blood) -564.700012207 (flow) ] TJ
0 -1.220600009 TD
[(\(lowe) -10.1999998093 (r) -504.299987793 (trans) -19 (-renal) -511.200012207 (pressu) -8.6999998093 (re) -508.6000061035 (gradient\)) -517 (and) -506.299987793 (de) -17 (crea) -13.6999998093 (se) -510.1000061035 (the) ] TJ
0 -1.2264000177 TD
[(pressu) -8.6999998093 (re) -375.5 (gradient) -382 (for) -376 (ultrafilt) -11.1999998093 (ration) -381.799987793 (\(higher) -378.799987793 (intra-) -11.3999996185 (tubular) ] TJ
T*
[(pressu) -8.6999998093 (re\).) -379.299987793 (In) -376.1000061035 (septic) -384.799987793 (shock) -36.7000007629 (,) -377.8999938965 (fluid) -379 (the) -9 (rapy) -381 (will) -380 (only) -378.799987793 (effe) -16.6000003815 (ct) 16.8999996185 (-) ] TJ
0 -1.220600009 TD
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0 -1.2264000177 TD
[(temic) -329 (hypoten) -12.6999998093 (sion.) -327 (Aggressiv) -9.8999996185 (e) -322.3999938965 (fluid) -326.8999938965 (resuscitatio) -15.3999996185 (n) -321.5 (beyond) ] TJ
T*
[(re) -11.1000003815 (versal) -381.700012207 (of) -392.299987793 (hypo) -8.8999996185 (volaemia) -377.6000061035 (to) -378.6000061035 (arbitrary) -383.200012207 (C) -28.7999992371 (V) 0 (P) -376.6000061035 (target) -14.6000003815 (s) -372.799987793 (could) ] TJ
0 -1.220600009 TD
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0 -1.2264000177 TD
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T*
[(to) -303.3999938965 (renal) -308.200012207 (dysfunctio) -13.8999996185 (n.) ] TJ
0.8156999946 -1.220600009 TD
[(The) -376.6000061035 (a) -15.8000001907 (ssociation) -391.200012207 (betw) -9.8999996185 (een) -387.8999938965 (ele) -14.6000003815 (vated) -386.700012207 (C) -34.5999984741 (V) 0 (P) -382.3999938965 (a) 0 (n) -7.5999999046 (d) -383 (renal) -389.200012207 (dys) -13.8000001907 (-) ] TJ
-0.8156999946 -1.2264000177 TD
[(functio) -11.6000003815 (n) -593.4000244141 (h) 0 (a) -18.6000003815 (s) -598.5 (been) -602.5999755859 (made) -599.799987793 (pre) -18.1000003815 (viously) -605.799987793 (in) -599.5999755859 (the) -599.0999755859 (setting) -605.700012207 (of) ] TJ
T*
[(chronic) -381.1000061035 (cardiac) -378.200012207 (failure) -375.700012207 ([4].) -371.6000061035 (Now) -377.5 (Legrand) -378.8999938965 (and) -373.299987793 (colleagu) -12.1999998093 (es) ] TJ
0 -1.220600009 TD
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0 -1.2264000177 TD
[(ser) -36.7999992371 (ved) -397.8999938965 (in) -391.299987793 (sep) -8.1000003815 (tic) -394.1000061035 (shoc) -10.3000001907 (k) -390.8999938965 (and) -396.3999938965 (it) -13.8999996185 (s) -396 (treatme) -11.8999996185 (nt.) -394.799987793 (Their) -389.5 (finding) -8 (s) ] TJ
T*
[(are) -420.200012207 (also) -424.299987793 (in) -420.200012207 (accord) -426.3999938965 (with) -418.799987793 (se) -12.6000003815 (con) -8.3000001907 (dary) -421.5 (analysis) -426.8999938965 (of) -421.200012207 (the) -367.700012207 (V) 62.2000007629 (a) -15.8000001907 (so-) ] TJ
0 -1.220600009 TD
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0 -1.2264000177 TD
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T*
[(ciated) -513.700012207 (with) -511.3999938965 (increa) -17.3999996185 (sed) -511.3999938965 (mortality) -518.0999755859 (in) -507 (patient) -17.2999992371 (s) -505.8999938965 (with) -511.3999938965 (septic) ] TJ
0 -1.220600009 TD
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0 -1.2264000177 TD
[(illness) -308.799987793 (se) -12.6000003815 (verity) -305.8999938965 (and) -303.8999938965 (demogr) -8.3999996185 (aphi) -8.6000003815 (cs.) ] TJ
0.8156999946 -1.2264000177 TD
[(Alth) -8.6999998093 (ough) -412.3999938965 (the) -9 (se) -411.799987793 (obser) -38.0999984741 (vation) -9.6000003815 (al) -409.5 (finding) -8 (s) -413.299987793 (are) -414.5 (hypothesis) -23.5 (-) ] TJ
-0.8156999946 -1.220600009 TD
[(gener) -8.3000001907 (ating) -375.5 (rather) -379.799987793 (tha) -9 (n) -373.6000061035 (confirmatory) -14.3000001907 (,) -372.1000061035 (they) -377.700012207 (add) -376.8999938965 (weig) -8.6999998093 (ht) -375 (to) ] TJ
0 -1.2264000177 TD
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T*
[(load) -428.799987793 (in) -420.200012207 (critic) -12.1000003815 (al) -421.1000061035 (illne) -8.6000003815 (ss) -421.700012207 (and) -425.3999938965 (AKI) -427.700012207 (in) -420.200012207 (part) -8.5 (icular) -429.5 ([6],) -423.6000061035 (effe) -16.6000003815 (ct) -12 (s) ] TJ
0 -1.220600009 TD
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0 -1.2264000177 TD
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T*
[(termine) -420.200012207 (whether) -413.3999938965 (uncritic) -12.5 (al) -409.5 (purs) -7.6999998093 (uit) -410 (of) -409.6000061035 (C) -34.5999984741 (V) 0 (P) -411.299987793 (target) -20.3999996185 (s) -407.5 (such) ] TJ
0 -1.220600009 TD
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0 -1.2264000177 TD
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T*
[(organ) -473.299987793 (injury.) -475.200012207 (Prospe) -20.5 (ctive) -472.6000061035 (data) -474.5 (are) -472.299987793 (require) -9.1000003815 (d) -469.799987793 (t) 0 (o) -471.200012207 (e) -10 (valuate) ] TJ
0 -1.220600009 TD
[(the) -385 (true) -391.799987793 (con) -8.3000001907 (tribution) -389.1000061035 (of) -380.700012207 (rais) -8.1999998093 (ed) -381.5 (venous) -388.700012207 (pressure) -384.200012207 (to) -384.3999938965 (renal) ] TJ
0 -1.2264000177 TD
[(and) -552.5999755859 (other) -554.5 (organ) -548.5 (dys) -8.1000003815 (function) -553 (an) -7.5999999046 (d) -545 (t) 0 (o) -552.200012207 (determin) -10.6999998093 (e) -548 (better) ] TJ
T*
[(endpoint) -22.2000007629 (s) -297.6000061035 (for) -306.5 (fluid) -303.799987793 (resusci) -12.1000003815 (tation) -307.6000061035 (in) -298.700012207 (sep) -8.1000003815 (sis.) ] TJ
/F9 1 Tf
7.4998998642 0 0 7.4998998642 56.6929016113 276.9448852539 Tm
(Abbreviations) Tj
/F3 1 Tf
0 0 0 rg
0 -1.2019000053 TD
(AKI:) Tj
0 0 0 1 k
1.7461999655 0 TD
[(Acu) -9.6000003815 (te) -300 (kidney) -305.799987793 (injury;) -299.799987793 (CVP:) -305.3999938965 (Central) -309.5 (venous) -302.799987793 (pressure.) ] TJ
/F9 1 Tf
-1.7461999655 -3.1974999905 TD
[(Competing) -309.5 (interests) ] TJ
/F3 1 Tf
0 -1.2019000053 TD
[(The) -300.799987793 (authors) -309.799987793 (declare) -300.3999938965 (that) -307.799987793 (they) -299.5 (have) -303.299987793 (no) -306.200012207 (competing) -304.6000061035 (interests.) ] TJ
/F9 1 Tf
0 -3.1974999905 TD
(Authors) Tj
/F10 1 Tf
3.4393999577 0 TD
<92> Tj
/F9 1 Tf
0.5291000009 0 TD
(contributions) Tj
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-3.9686000347 -1.2019000053 TD
[(RR) -300.200012207 (conceived) -309.3999938965 (and) -302.700012207 (wrote) -302 (the) -305.6000061035 (article.) -304.200012207 (JRP) -304.8999938965 (conceived) -301.799987793 (and) -302.700012207 (edite) -9.3000001907 (d) -298.1000061035 (the) -298.1000061035 (article) -311.5 (and) ] TJ
T*
[(approved) -309.299987793 (the) -298.1000061035 (final) -303.799987793 (version.) -309 (Both) -305.5 (authors) -302.200012207 (read) -305.6000061035 (and) -302.700012207 (approved) -309.299987793 (the) -298.1000061035 (final) ] TJ
0 -1.1943999529 TD
(manuscript.) Tj
/F9 1 Tf
0 -3.2051000595 TD
(Authors) Tj
/F10 1 Tf
3.4393999577 0 TD
<92> Tj
/F9 1 Tf
0.5291000009 0 TD
[(informa) -11 (tion) ] TJ
/F3 1 Tf
-3.9686000347 -1.1943000555 TD
[(Rajkumar) -304.799987793 (Raj) -9.1000003815 (endram) -300.6000061035 (BSc) -305.799987793 (MBBS) -304.299987793 (MRCP) -298.6000061035 (FRCA) -308.299987793 (FFICM,) -303.3999938965 (Specialty) -307.8999938965 (registrar) -308.5 (in) ] TJ
0 -1.2019000053 TD
[(Anaesthesia) -12.1000003815 (,) -295.1000061035 (Royal) -303.5 (Free) -303.700012207 (Hospital,) -311.8999938965 (London.) -305 (John) -301.5 (R) -301.299987793 (Prowle) -304.200012207 (MA) -302.3999938965 (MSc) -300.3999938965 (MD) -308.5 (MRCP) ] TJ
T*
[(FFICM,) -303.3999938965 (Consulta) -12.1999998093 (nt) -300.8999938965 (in) -296.6000061035 (Renal) -306.799987793 (Medicine) -308 (and) -302.700012207 (Intensive) -306.1000061035 (Care,) -300 (The) -308.3999938965 (Royal) -303.5 (London) ] TJ
T*
[(Hospital,) -304.3999938965 (London.) ] TJ
/F9 1 Tf
0 -2.3963000774 TD
[(Author) -308 (details) ] TJ
/F3 1 Tf
5.6248002052 0 0 4.9991998672 56.6929016113 100.2898025513 Tm
0 0 0 rg
(1) Tj
7.4998998642 0 0 7.4998998642 59.3574981689 96.9449005127 Tm
[(Departm) -13.1000003815 (ent) -298.1000061035 (of) -305.1000061035 (Anaesthesia,) -307.200012207 (Royal) -303.5 (Free) -303.700012207 (Hospital,) -304.3999938965 (Hampstea) -12 (d,) -298.3999938965 (London) -304.700012207 (NW3) ] TJ
-0.3553000093 -1.2019000053 TD
[(2QG,) -304.8999938965 (UK.) ] TJ
5.6248002052 0 0 4.9991998672 85.2660980225 91.2755966187 Tm
(2) Tj
7.4998998642 0 0 7.4998998642 87.9873962402 87.9307022095 Tm
[(Adult) -302.700012207 (Critical) -307.700012207 (Care) -299.700012207 (Unit,) -307.200012207 (The) -300.799987793 (Royal) -303.5 (London) -304.700012207 (Hospital,) -304.3999938965 (Barts) -303.299987793 (Health) ] TJ
-4.1726999283 -1.1943000555 TD
[(NHS) -300.299987793 (Trust,) -310.299987793 (Whitechapel) -308.799987793 (Road,) -301.8999938965 (London) -304.700012207 (E1) -302.700012207 (1BB,) -297.700012207 (UK.) ] TJ
/F2 1 Tf
0 0 0 1 k
0 -2.4038000107 TD
(Published:) Tj
/F9 1 Tf
33.0713005066 84.798500061 TD
(References) Tj
/F3 1 Tf
7.1248998642 0 0 7.4998998642 304.7243041992 687.9683837891 Tm
[(1.) -1463.5999755859 (Legrand) -295.6000061035 (M,) -305.299987793 (Dupuis) -305.200012207 (C,) -298.3999938965 (Simon) -300.6000061035 (C,) -298.3999938965 (Gayat) -307.200012207 (E,) -299 (Mateo) -303.6000061035 (J,) -294.6000061035 (Lukaszewicz) -306.200012207 (AC,) -304.299987793 (Payen) -303.3999938965 (D:) ] TJ
/F2 1 Tf
2.1085999012 -1.2019000053 TD
[(Association) -302.700012207 (between) -297.5 (systemic) -301.8999938965 (hemodynamics) -300.700012207 (and) -300.700012207 (septic) -306 (acute) -297 (kidney) ] TJ
T*
[(injury) -298.6000061035 (in) -301.1000061035 (critically) -298.8999938965 (ill) -307.6000061035 (patients:) -301.1000061035 (a) -300.799987793 (retrospective) -303.799987793 (observational) -297.799987793 (study.) ] TJ
/F4 1 Tf
27.5312995911 0 TD
(Crit) Tj
-27.5312995911 -1.2019000053 TD
(Care) Tj
/F3 1 Tf
2.0290000439 0 TD
(2013,) Tj
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2.3791999817 0 TD
(17:) Tj
/F3 1 Tf
1.2173999548 0 TD
(R278.) Tj
-7.7342000008 -1.1943000555 TD
[(2.) -1463.5999755859 (Dellinger) -300.8999938965 (RP,) -298.1000061035 (Levy) -298.6000061035 (MM,) -307.1000061035 (Rhodes) -300.3999938965 (A,) -301.299987793 (Annane) -295.6000061035 (D,) -303 (Gerlach) -303.1000061035 (H,) -299.1000061035 (Opal) -302.299987793 (SM,) -300.799987793 (Sevransky) ] TJ
2.1085999012 -1.2019000053 TD
[(JE,) -298.1000061035 (Sprung) -300.700012207 (CL,) -305 (Douglas) -300.700012207 (IS,) -297.8999938965 (Jaeschke) -307.3999938965 (R,) -296.799987793 (Osborn) -306.5 (TM,) -300.799987793 (Nunnally) -302.299987793 (ME,) -300.799987793 (Townsend) ] TJ
T*
[(SR,) -300.299987793 (Reinhart) -299.5 (K,) -299.799987793 (Kleinpell) -301.200012207 (RM,) -298.6000061035 (Angus) -301.6000061035 (DC,) -305.8999938965 (Deutschman) -302.8999938965 (CS,) -301.8999938965 (Machado) -298.299987793 (FR,) ] TJ
T*
[(Rubenfeld) -301.299987793 (GD,) -301.6000061035 (Webb) -300.5 (SA,) -296.8999938965 (Beale) -305.8999938965 (RJ,) -295.8999938965 (Vincent) -298.200012207 (JL,) -309.1000061035 (Moreno) -296.3999938965 (R,) -304.700012207 (Surviving) -303.6000061035 (Sepsis) ] TJ
0 -1.1943000555 TD
[(Campaign) -303.200012207 (Guidelines) -295.8999938965 (Committee) -303 (including) -301.200012207 (the) -303.200012207 (Pediatric) -302.799987793 (Subgroup:) ] TJ
/F2 1 Tf
0 -1.2019000053 TD
[(Surviving) -297.3999938965 (sepsis) -300.8999938965 (campaign:) -300.8999938965 (international) -301.6000061035 (guidelines) -302.1000061035 (for) -302.1000061035 (management) -302 (of) ] TJ
T*
[(severe) -295.799987793 (sepsis) -300.8999938965 (and) -300.700012207 (septic) -306 (shock:) -304.200012207 (2012.) ] TJ
/F4 1 Tf
15.8662996292 0 TD
[(Crit) -299.299987793 (Care) -301 (Med) ] TJ
/F3 1 Tf
5.5938000679 0 TD
(2013,) Tj
/F2 1 Tf
2.3791999817 0 TD
(41:) Tj
/F3 1 Tf
1.225399971 0 TD
(580) Tj
/F11 1 Tf
1.4322999716 0 TD
<96> Tj
/F3 1 Tf
0.5012999773 0 TD
(637.) Tj
-29.1068000793 -1.2019000053 TD
[(3.) -1463.5999755859 (Gottschalk) -295.8999938965 (CW,) -306 (Mylle) -301 (M:) ] TJ
/F2 1 Tf
12.0389995575 0 TD
[(Micropuncture) -309.1000061035 (study) -298 (of) -305.799987793 (pressures) -301 (in) -301.1000061035 (proximal) ] TJ
-9.9303998947 -1.1943000555 TD
[(tubules) -299.6000061035 (and) -300.700012207 (peritubular) -300.3999938965 (capillaries) -308.1000061035 (of) -297.8999938965 (the) -297 (rat) -301.299987793 (kidney) -300.299987793 (and) -300.799987793 (their) -302.8999938965 (relation) -303.1000061035 (to) ] TJ
0 -1.2019000053 TD
[(ureteral) -301.8999938965 (and) -300.700012207 (renal) -297.1000061035 (venous) -302.1000061035 (pressures.) ] TJ
/F4 1 Tf
15.5320997238 0 TD
[(Am) -301.200012207 (J) -303.6000061035 (Physiol) ] TJ
/F3 1 Tf
5.1721000671 0 TD
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