Clones assemble! The clonal complexity of blood during ontogeny and disease.
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Published version
Embargoed until: 5555-01-01
Reason: Version not permitted
Embargoed until: 5555-01-01
Reason: Version not permitted
Volume
83
Pagination
35 - 47
Publisher URL
DOI
10.1016/j.exphem.2020.01.009
Journal
Experimental Hematology
Metadata
Show full item recordAbstract
Hematopoietic stem and progenitor cells (HSPCs) govern the daily expansion and turnover of billions of specialized blood cells. Given their clinical utility, much effort has been made toward understanding the dynamics of hematopoietic production from this pool of stem cells. An understanding of hematopoietic stem cell clonal dynamics during blood ontogeny could yield important insights into hematopoietic regulation, especially during aging and repeated exposure to hematopoietic stress-insults that may predispose individuals to the development of hematopoietic disease. Here, we review the current state of research regarding the clonal complexity of the hematopoietic system during embryogenesis, adulthood, and hematologic disease.