Browsing Centre for Immunobiology by Title
Now showing items 612-631 of 1111
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KAP1 regulates endogenous retroviruses in adult human cells and contributes to innate immune control.
(2018-10)Endogenous retroviruses (ERVs) have accumulated in vertebrate genomes and contribute to the complexity of gene regulation. KAP1 represses ERVs during development by its recruitment to their repetitive sequences through ... -
KDM2 proteins constrain transcription from CpG island gene promoters independently of their histone demethylase activity
(2019-02-28)ABSTRACT CpG islands (CGI) are associated with the majority of mammalian gene promoters and function to recruit chromatin modifying enzymes. It has therefore been proposed that CGIs regulate gene expression through ... -
Kidney Transplantation in a Patient Lacking Cytosolic Phospholipase A2 Proves Renal Origins of Urinary PGI-M and TX-M.
(2018-02-16)RATIONALE: The balance between vascular prostacyclin, which is antithrombotic, and platelet thromboxane A2, which is prothrombotic, is fundamental to cardiovascular health. Prostacyclin and thromboxane A2 are formed after ... -
Lenacapavir in first-line therapy
(2023) -
Lentiviral vectors transduce proliferating dendritic cell precursors leading to persistent antigen presentation and immunization.
(2009-09)Lentiviral vectors (LVs) are tools for in vivo gene delivery, to correct genetic defects or to deliver antigens for vaccination. It was reported that systemic injection of LVs in mice transduced cells in liver and spleen. ... -
Liver sampling: a vital window into HBV pathogenesis on the path to functional cure.
(2018-04)In order to optimally refine the multiple emerging drug targets for hepatitis B virus (HBV), it is vital to evaluate virological and immunological changes at the site of infection. Traditionally liver biopsy has been the ...