Management of hypogonadism from birth to adolescence.
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Volume
32
Pagination
355 - 372
DOI
10.1016/j.beem.2018.05.011
Journal
Best Practice & Research Clinical Endocrinology & Metabolism
Issue
Metadata
Show full item recordAbstract
Management of patients with hypogonadism is dependent on the underlying cause. Whilst functional hypogonadism presenting as delayed puberty in adolescence is relatively common, permanent hypogonadism presenting in infancy or adolescence is unusual. The main differential diagnoses of delayed puberty include self-limited delayed puberty (DP), idiopathic hypogonadotropic hypogonadism (IHH) and hypergonadotropic hypogonadism. Treatment of self-limited DP involves expectant observation or short courses of low dose sex steroid supplementation. More complex and involved management is required in permanent hypogonadism to achieve both development of secondary sexual characteristics and to maximize the potential for fertility. This review will cover the options for management involving sex steroid or gonadotropin therapy, with discussion of benefits, limitations and specific considerations of the different treatment options.
Authors
Howard, SR; Dunkel, LCollections
- Centre for Endocrinology [552]