Browsing Centre for Haemato-Oncology by Title
Now showing items 64-83 of 214
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Follicular lymphoma genomics
(2020-08-23) -
Follicular lymphoma genomics
(2019-06-01) -
Fumarate hydratase is a critical metabolic regulator of hematopoietic stem cell functions.
(2017-03-06)Strict regulation of stem cell metabolism is essential for tissue functions and tumor suppression. In this study, we investigated the role of fumarate hydratase (Fh1), a key component of the mitochondrial tricarboxylic ... -
Functional screen identifies regulators of murine hematopoietic stem cell repopulation.
(2016-03-07)Understanding the molecular regulation of hematopoietic stem and progenitor cell (HSPC) engraftment is paramount to improving transplant outcomes. To discover novel regulators of HSPC repopulation, we transplanted >1,300 ... -
Generation and Surgical Analysis of Genetic Mouse Models to Study NF-κB-Driven Pathogenesis of Diffuse Large B Cell Lymphoma.
(2021)Enforced activation of NF-κB signaling can be achieved by constitutive NF-κB-inducing kinases, IKK2 and NIK, or via lymphoma-associated mutants of MYD88, CARD11, and CD79B. In order to model Diffuse Large B Cell Lymphoma ... -
Genomic analyses identify recurrent MEF2D fusions in acute lymphoblastic leukemia
(Nature Publishing Group, 2017-11-08)Chromosomal rearrangements are initiating events in acute lymphoblastic leukaemia (ALL). Here using RNA sequencing of 560 ALL cases, we identify rearrangements between MEF2D (myocyte enhancer factor 2D) and five genes ... -
The global clonal complexity of the murine blood system declines throughout life and after serial transplantation.
(2019-05-02)Although many recent studies describe the emergence and prevalence of "clonal hematopoiesis of indeterminate potential" in aged human populations, a systematic analysis of the numbers of clones supporting steady-state ... -
Glycosylation of surface Ig creates a functional bridge between human follicular lymphoma and microenvironmental lectins.
(2010-10-26)Surface Ig (sIg) of follicular lymphoma (FL) is vital for tumor cell survival. We found previously that the Ig in FL is unusual, because the variable region genes carry sequence motifs for N-glycan addition. These are ...