dc.contributor.author | Chongwe, G | en_US |
dc.contributor.author | Michelo, C | en_US |
dc.contributor.author | Kelly, P | en_US |
dc.date.accessioned | 2018-03-06T11:48:45Z | |
dc.date.available | 2016-12-09 | en_US |
dc.date.issued | 2017-01-07 | en_US |
dc.date.submitted | 2018-02-19T12:47:24.108Z | |
dc.identifier.other | 10.1186/s13104-016-2329-3 | |
dc.identifier.other | https://bmcresnotes.biomedcentral.com/articles/10.1186/s13104-016-2329-3 | |
dc.identifier.uri | http://qmro.qmul.ac.uk/xmlui/handle/123456789/34321 | |
dc.description | This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. | en_US |
dc.description.abstract | BACKGROUND: The intestinal carriage of nontuberculous mycobacteria (NTM) is associated with disease, especially in severely immunocompromised individuals. These organisms, although often considered contaminants, have been known to cause various types of illnesses. We aimed to determine the prevalence of and associated factors for NTM among patients booked for colonoscopy at the University Teaching Hospital (UTH) in Lusaka. METHODS: We randomly recruited 97 patients attending routine endoscopy procedures between November 2012 and October 2013 and after consent, administered a structured questionnaire. We collected stool and intestinal lavage samples, as well as biopsy samples from the descending colon and the caecal area during the endoscopy procedure. Samples were cultured using the mycobacteria growth indicator tube (MGIT) method followed by the GenoType Mycobacterium CM/AS assay for identification of NTM. Results were expressed as means and standard deviations; proportions were expressed as percentages with corresponding 95% confidence intervals. We used Fisher's exact Chi square test for cross-tabulations where appropriate. All statistical tests were two-sided, with a significance level set at p < 0.05. RESULTS: Out of the 97 patients, 45 (46.4%) were female and 52 (53.6%) were males with mean ages 49.1 (±16.7, range 24-85) and 44.4 (±15.0, range 18-80) years respectively. The prevalence of NTM was 7.2% (95% CI 1.9-12.4), while that of Mycobacterium tuberculosis (MTB) was 6.2% (95% CI 2.3-13.0). Carriage of NTM was not significantly associated with age, sex or presenting symptoms such as diarrhoea, abdominal pain, weight loss as well as HIV status. There were no identifiable predictors of NTM carriage. CONCLUSION: The results have shown that NTM and MTB are present in the intestines of the patients booked for colonoscopy at the University Teaching Hospital in Lusaka, but their presence is not related to presenting symptoms. Given that this may be an indicator of a bigger burden of NTM in this population, there is a need to explore this burden and the contribution it could have on abdominal disease in general as well as examine potential factors that might be important predictors. | en_US |
dc.description.sponsorship | Financial support for this study was provided by the Research Support Centre at the University of Zambia School of Medicine (UNZA-SOM), through the Southern African Consortium for Research Excellence (SACORE), which is part of the African Institutions Initiative Grant of the Wellcome Trust (Company Number 2711000), a charity (No. 210183) registered in England | en_US |
dc.format.extent | 27 - ? | en_US |
dc.language | eng | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | BMC Res Notes | en_US |
dc.rights | Creative Commons Attribution License | |
dc.subject | Colonoscopy | en_US |
dc.subject | Endoscopy | en_US |
dc.subject | Gastrointestinal | en_US |
dc.subject | Nontuberculous mycobacteria | en_US |
dc.subject | Adult | en_US |
dc.subject | Aged | en_US |
dc.subject | Aged, 80 and over | en_US |
dc.subject | Biopsy | en_US |
dc.subject | Colonoscopy | en_US |
dc.subject | Female | en_US |
dc.subject | Humans | en_US |
dc.subject | Male | en_US |
dc.subject | Middle Aged | en_US |
dc.subject | Models, Statistical | en_US |
dc.subject | Mycobacterium Infections, Nontuberculous | en_US |
dc.subject | Nontuberculous Mycobacteria | en_US |
dc.subject | Prevalence | en_US |
dc.subject | Surveys and Questionnaires | en_US |
dc.subject | Zambia | en_US |
dc.title | Diagnostic yield of nontuberculous mycobacteria in patients booked for endoscopy at the University Teaching Hospital, Lusaka. | en_US |
dc.type | Article | |
dc.rights.holder | The Author(s) 2017 | |
dc.identifier.doi | 10.1186/s13104-016-2329-3 | en_US |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/28061885 | en_US |
pubs.issue | 1 | en_US |
pubs.notes | No embargo | en_US |
pubs.publication-status | Published online | en_US |
pubs.volume | 10 | en_US |
dcterms.dateAccepted | 2016-12-09 | en_US |