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"This is the peer reviewed version of the following article: Carassiti, D., Altmann, D. R., Petrova, N., Pakkenberg, B., Scaravilli, F. and Schmierer, K., Neuronal loss, demyelination and volume change in the multiple sclerosis neocortex. Neuropathol Appl Neurobiol. doi:10.1111/nan.12405, which has been published in final form at https://doi.org/10.1111/nan.12405. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving."