Tumour Cell Heterogeneity.
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Volume
5
DOI
10.12688/f1000research.7210.1
Journal
F1000Res
ISSN
2046-1402
Metadata
Show full item recordAbstract
The population of cells that make up a cancer are manifestly heterogeneous at the genetic, epigenetic, and phenotypic levels. In this mini-review, we summarise the extent of intra-tumour heterogeneity (ITH) across human malignancies, review the mechanisms that are responsible for generating and maintaining ITH, and discuss the ramifications and opportunities that ITH presents for cancer prognostication and treatment.